Article
mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil
Registro en:
AIRES, Caio Augusto Martins; et al. MgrB mutations mediating polymyxin B resistance in Klebsiella pneumoniae isolates from rectal surveillance swabs in Brazil. Antimicrobial Agents and Chemotherapy, v.61, n.3, 15p, Sept. 2016.
0066-4804
10.1128/AAC.01456-16
1098-6596
Autor
Aires, Caio Augusto Martins
Pereira, Polyana Silva
Asensi, Marise Dutra
Assef, Ana Paula D'Alincourt Carvalho
Resumen
We aimed to investigate polymyxin B (PMB) resistance and its molecular mechanisms in 126 Klebsiella pneumoniae isolates from rectal swabs in Brazil. Ten isolates exhibited PMB resistance with interruption of mgrB gene by insertion sequences or missense mutations. Most of the PMB-resistant isolates harbored blaKPC-2 (n = 8) and belonged to clonal complex 258 (CC258) (n = 7). These results highlight the importance of monitoring the spread of polymyxin-resistant bacteria in hospitals, since few options remain to treat multidrug-resistant isolates.