Article
Severe preeclampsia: are hemostatic and inflammatory parameters associated?
Registro en:
PINHEIRO, Melina Barros et al. Severe preeclampsia: are hemostatic and inflammatory parameters associated?Clin Chim Acta, vol. 427, p. 65-70, 2014
0009-8981
10.1016/j.cca.2013.09.050
Autor
Pinheiro, Melina de Barros
Carvalho, Maria das Graças
Martins Filho, Olindo Assis
Freitas, Letícia Gonçalves
Godoi, Lara Carvalho
Alpoim, Patrícia Nessralla
Gomes, Karina Braga
Dusse, Luci Maria Sant' Ana
Resumen
Background: Preeclampsia (PE) is characterized by hypertension and proteinuria. A predisposition to endothelial dysfunction, which may trigger abnormal activation of the hemostatic and/or inflammatory systems, is thought to play a crucial part in pathogenesis of PE. We investigated the relationship between hemostatic and inflammatory parameters in women with severe PE.
Methods: D-Dimer, PAI-1, IL-8, IL-6, TNF-α, andIFN-γ concentrationswere measured in 59 pregnant women with severe PE (sPE), 49 normotensive pregnant and 48 non-pregnant women.
Results: D-Dimer and PAI-1 were higher in women with sPE compared to normotensive pregnant and nonpregnantwomen. IL-8, IL-6, and IFN-γ alsowere higher in womenwith sPE compared to normotensive pregnant women. However, only IL-6 and IFN-γ were higher in women with sPE compared to non-pregnant women. Moreover, D-Dimer and PAI-1 showed an elevated area under ROC curve proving to be excellent for discriminating sPE. Correlation analysis showed a weak correlation between D-Dimer and IL-8 and between PAI-1 and IFN-γ in sPE.
Conclusion: D-Di and PAI-1 concentrations showed to be an important tool for monitoring sPE.