Article
Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis
Registro en:
ARRUDA, S. M. et al. Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis. Retrovirology, v. 8, Suppl 1, p. A80, 2011.
1742-4690
10.1186/1742-4690-8-S1-A80
Autor
Arruda, Sérgio Marcos
Loureiro, Camila
Almeida, Marcos
Mendes, Dayana Santos
Grassi, Maria Fernanda Rios
Lapa, José R
Kritski, Afrânio Lineu
Verdonck, Kristien
Gotuzzo, Eduardo
Castro Filho, Bernardo Galvão
Resumen
Background
HTLV-1 infection alters the immune function and
increases the risk of several infectious diseases. In this
meta-analysis, we assess the association between HTLV-
1/2 and active tuberculosis (TB).
Methods
Four databases were searched for relevant articles that
describe the frequency of HTLV- 1/2 infection among
TB patients and control groups of healthy individuals or
patients without a history of TB. Data were analyzed
using the EasyMA software.
Results
The search yielded two hundred and eight articles. Six
met the inclusion criteria and were included in the
meta-analysis. The estimated relative risk of HTLV- 1/2
infection in TB patients was 3.25 times higher than in
the population based control groups.
Conclusion
Patients with active TB have a higher risk of HTLV- 1/2
infection. Prospective studies involving latent tuberculosis
infection (LTBI) in HTLV-1-infected individuals are
necessary to evaluate the potential benefit of TB
chemoprophylaxis.