Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSaad, Wilson Abrão
dc.creatorDe Arruda Camargo, Luiz Antonio
dc.date2014-05-27T11:20:39Z
dc.date2016-10-25T18:18:37Z
dc.date2014-05-27T11:20:39Z
dc.date2016-10-25T18:18:37Z
dc.date2003-05-01
dc.date.accessioned2017-04-06T01:05:39Z
dc.date.available2017-04-06T01:05:39Z
dc.identifierArquivos Brasileiros de Cardiologia, v. 80, n. 4, p. 401-405, 2003.
dc.identifier0066-782X
dc.identifier1678-4170
dc.identifierhttp://hdl.handle.net/11449/67281
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67281
dc.identifier10.1590/S0066-782X2003000400004
dc.identifierS0066-782X2003000400004
dc.identifier2-s2.0-4444274375.pdf
dc.identifier2-s2.0-4444274375
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2003000400004
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/888751
dc.descriptionObjective - We determined the effects of losartan and PD 123319 (antagonists of the AT1 and AT2 angiotensin receptors, respectively), and [Sar1, Ala8] ANG II (a relatively peptide antagonist of angiotensin receptors) injected into the paraventricular nucleus (PVN) on water and 3% NaCl intake, and the diuretic, natriuretic, and pressor effects induced by administration of angiotensin II (ANG II) into the medial septal area (MSA) of conscious rats. Methods - Holtzman rats were used. Animals were anesthetized with tribromoethanol (20 mg) per 100 grams of body weight, ip. A stainless steel guide cannula was implanted into the MSA and PVN. All drugs were injected in 0.5-μl volumes for 10-15 seconds. Seven days after brain surgery, water and 3% NaCl intake, urine and sodium excretion, and arterial blood pressure were measured. Results - Losartan (40 nmol) and [Sar1, Ala8] ANG II (40 nmol) completely eliminated whereas PD 123319 (40 nmol) partially blocked the increase in water and sodium intake and the increase in arterial blood pressure induced by ANG II (10 nmol) injected into the MSA. The PVN administration of PD 123319 and [Sar1, Ala8] ANG II blocked whereas losartan attenuated the diuresis and natriuresis induced by MSA administration of ANG II. Conclusion - MSA involvement with PVN on water and sodium homeostasis and arterial pressure modulation utilizing ANGII receptors is suggested.
dc.languageeng
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBlood pressure
dc.subjectCentral nervous system
dc.subjectSodium balance
dc.subject1 (4 dimethylamino 3 methylbenzyl) 5 diphenylacetyl 4,5,6,7 tetrahydro 1h imidazo[4,5 c]pyridine 6 carboxylic acid
dc.subjectangiotensin II
dc.subjectbromethol
dc.subjectlosartan
dc.subjectreceptor subtype
dc.subjectsodium chloride
dc.subjectstainless steel
dc.subjectangiotensin receptor
dc.subjectantihypertensive agent
dc.subjectimidazole derivative
dc.subjectpyridine derivative
dc.subjectsaralasin
dc.subjectsodium
dc.subjectvasoconstrictor agent
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarterial pressure
dc.subjectattenuation
dc.subjectblood pressure measurement
dc.subjectbody weight
dc.subjectbrain surgery
dc.subjectcannula
dc.subjectcontrolled study
dc.subjectdiuresis
dc.subjectfluid intake
dc.subjectmale
dc.subjectmeasurement
dc.subjectnatriuresis
dc.subjectnonhuman
dc.subjectrat
dc.subjectseptum pellucidum
dc.subjectsodium excretion
dc.subjectsodium intake
dc.subjectthalamus midline nucleus
dc.subjecturinary excretion
dc.subjectanimal
dc.subjectanterior hypothalamus
dc.subjectblood pressure
dc.subjectdrinking
dc.subjectdrug antagonism
dc.subjectdrug effect
dc.subjecthomeostasis
dc.subjectmetabolism
dc.subjectSprague Dawley rat
dc.subjectAngiotensin II
dc.subjectAnimals
dc.subjectAntihypertensive Agents
dc.subjectBlood Pressure
dc.subjectDiuresis
dc.subjectDrinking
dc.subjectHomeostasis
dc.subjectImidazoles
dc.subjectLosartan
dc.subjectMale
dc.subjectParaventricular Hypothalamic Nucleus
dc.subjectPyridines
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReceptors, Angiotensin
dc.subjectSaralasin
dc.subjectSeptum of Brain
dc.subjectSodium
dc.subjectVasoconstrictor Agents
dc.titleInfluence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area
dc.typeOtro


Este ítem pertenece a la siguiente institución