Evaluation of an interferon gamma assay in the diagnosis of latent tuberculosis infection in patients with rheumatoid arthritis

dc.creatorMarques, Cláudia Diniz Lopes
dc.creatorDuarte, Ângela Luzia Branco Pinto
dc.creatorLorena, Virginia Maria Barros de
dc.creatorSouza, Joelma Rodrigues
dc.creatorSouza, Wayner Vieira
dc.creatorGomes, Yara de Miranda
dc.creatorCarvalho, Eduardo Maia Freese de
dc.date2018-07-31T13:24:28Z
dc.date2018-07-31T13:24:28Z
dc.date2009
dc.date.accessioned2023-09-26T23:03:20Z
dc.date.available2023-09-26T23:03:20Z
dc.identifierMARQUES, C. D. L. et al. Evaluation of an interferon gamma assay in the diagnosis of latent tuberculosis infection in patients with rheumatoid arthritis. Rheumatology International, v. 30, n. 1, p. 57–62, nov. 2009.
dc.identifier1437-160X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27730
dc.identifier10.1007/s00296-009-0910-y
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8886320
dc.descriptionThe tuberculin skin test is not an ideal screening test for the patients with rheumatoid arthritis to identify cases of latent tuberculosis infection (LTBI) prior to the start of treatment with anti-TNFs, as it responds inadequately to late hypersensitivity, which is fundamental for producing a response to the inoculated antigen. Assays based on detection of the production of IFNγ in vitro by mononuclear peripheral cells stimulated by specific antigens are more specific than PPD in detecting LTBI. The aim of this study was to evaluate the performance of T-SPOT.TB in diagnosis of LTBI in patients with rheumatoid arthritis, comparing with the PPD. The specificity of the T-SPOT.TB varied from 87 to 90% and the negative-predictive value (NPV) from 94.4 to 100%. It can be concluded that the T-SPOT.TB showed high specificity and NPV, proving the capability of identifying false-negative cases of PPD, raising the level of safety for the use of anti-TNFs.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.rightsrestricted access
dc.subjectArtrite Reumatóide
dc.subjectDiagnóstico
dc.subjectTuberculose
dc.subjectensaio Interferon-gamma
dc.subjectRheumatoid arthritis
dc.subjectTuberculosis
dc.subjectDiagnosis
dc.subjectInterferon-gamma assay
dc.subjectAdulto
dc.subjectAntígenos Bacterianos / imunologia
dc.subjectAgentes Antirreumáticos / uso terapêutico
dc.subjectArtrite Reumatóide / complicações
dc.subjectArtrite Reumatóide / quimioterapia
dc.subjectArtrite Reumatóide / imunologia
dc.subjectBiomarcadores / análise
dc.subjectBrasil
dc.subjectDistribuição Qui-Quadrado
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectReações negativas falsas
dc.subjectFêmea
dc.subjectHumanos
dc.subjectInterferon-gama / secreção
dc.subjectTuberculose latente / complicações
dc.subjectTuberculose Latente / diagnóstico
dc.subjectTuberculose Latente / imunologia
dc.subjectTuberculose Latente / microbiologia
dc.subjectMasculino
dc.subjectMeia idade
dc.subjectMycobacterium tuberculosis / imunologia
dc.subjectValor Preditivo de Testes
dc.subjectKits de Reagentes, Diagnóstico
dc.subjectSensibilidade e Especificidade
dc.subjectLinfócitos T / imunologia
dc.subjectLinfócitos T / microbiologia
dc.subjectTeste de tuberculina
dc.subjectFator de Necrose Tumoral alfa / antagonistas e inibidores
dc.subjectFator de Necrose Tumoral alfa / metabolismo
dc.titleEvaluation of an interferon gamma assay in the diagnosis of latent tuberculosis infection in patients with rheumatoid arthritis
dc.typeArticle


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