Article
Dengue hemorrhagic fever is associated with polymorphisms in JAK1
Registro en:
SILVA, L. K. et al. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. European Journal of Human Genetics, v. 18, n. 11, p. 12221-1227, nov. 2010.
1476-5438
10.1038/ejhg.2010.98
Autor
Silva, Luciano Kalabric
Blanton, Ronald Edward
Parrado, Antonio R
Melo, Paulo S
Morato, Vanessa G
Reis, Eliana Almeida Gomes
Dias, Juarez Pereira
Castro, Jesuina M
Vasconcelos, Pedro F. C
Goddard, Katrina A. B
Barreto, Maurício Lima
Reis, Mitermayer Galvão dos
Teixeira, Glória
Resumen
To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN) response pathway as well as other important candidate genes. By single locus analysis comparing DHF with DF, 11 of the 51 markers with P<0.05 were in the JAK1 gene. Five markers were significantly associated by false discovery rate criteria (q<0.20 when P<6 × 10(-4)). The JAK1 SNPs showed differential distribution by ethnicity and ancestry consistent with epidemiologic observations in the Americas. The association remained significant after controlling for ancestry and income. No association was observed with markers in the gene encoding CD209 (DC-SIGN). An association between DHF and JAK1 polymorphisms is in agreement with expression profiles showing generalized decreased type 1 IFN-stimulated gene expression in these patients.