Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters

dc.creatorSilva, Diana Rodrigues da
dc.creatorCastro, Solange Lisboa de
dc.creatorAlves, Monique Castro da Silva
dc.creatorBatista, Wanderson da Silva
dc.creatorOliveira, Gabriel Melo de
dc.date2016-09-06T15:08:20Z
dc.date2016-09-06T15:08:20Z
dc.date2012
dc.date.accessioned2023-09-26T22:58:03Z
dc.date.available2023-09-26T22:58:03Z
dc.identifierSILVA, Diana Rodrigues da; et al. Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters. Mem Inst Oswaldo Cruz, v.107, n.2, p.211-216, Mar. 2012.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15699
dc.identifier10.1590/S0074-02762012000200010
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8885308
dc.descriptionTrypanosoma cruzi infection has a large public health impact in Latin American countries. Although the transmission rates via blood transfusions and insect vectors have declined sharply in the past 20 years due to policies of the Southern Cone countries, a large number of people are still at risk for infection. Currently, no accepted experimental model or descriptions of the clinical signs that occur during the course of acute murine infection are available. The aim of this work was to use non-invasive methods to evaluate the clinical signs of Balb/c mice infected with the Y strain of T. cruzi. The infected mice displayed evident clinical changes beginning in the third week of infection. The mice were evaluated based on physical characteristics, spontaneous activity, exploratory behaviour and physiological alterations. We hope that the results presented in this report provide parameters that complement the effective monitoring of trypanocidal treatment and other interventions used to treat experimental Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectDoença de Chagas
dc.subjectSinais clínicos
dc.subjectParâmetros não-invasivos
dc.subjectTrypanosoma cruzi
dc.subjectChagas Disease
dc.subjectClinical signs
dc.subjectnon-invasive parameters
dc.subjectMurine model
dc.titleAcute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters
dc.typeArticle


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