Prevalence of TTV in blood donors and patients with acute viral hepatitis and genotyping by phylogenetic analysis

dc.creatorLyra, Andre C.
dc.creatorPinho, João R. R.
dc.creatorMello, Isabel M. V. G. C.
dc.creatorSilva, Luciano Kalabric
dc.creatorBraga, Eduardo L.
dc.creatorLyra, Marcos C.
dc.creatorOliveira, Maxuel
dc.creatorSilva, Luiz C. da
dc.creatorCarrilho, Flair J.
dc.date2020-11-05T12:28:59Z
dc.date2020-11-05T12:28:59Z
dc.date2003
dc.date.accessioned2023-09-26T22:55:59Z
dc.date.available2023-09-26T22:55:59Z
dc.identifierLYRA, André C. et al. Prevalence of TTV in blood donors and patients with acute viral hepatitis and genotyping by phylogenetic analysis. GED, v. 22, n. 4, p. 129-132, 2003.
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44313
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8884916
dc.description0 objetivo desse estudo foi avaliar a prevalencia da infeccao pelo TTV em pacientes com hepatite aguda A e B, e genotipar os isolados do TTV atraves de analise filogendtica. Foram avaliados soros de 82 pacientes que apresentaram hepatite aguda A (N = 40) e B (N = 42), e 71 doadores de sangue. 0 TTV foi deterrninado atraves "nested-PCR", e a analise filogendtica foi realizada utilizando o mdtodo "neighborj oining': 0 TTV foi detectado ern 23% dos pacientes corn hepatite aguda e em 31% dos doadores. Os niveis medios de amino- transferases foram semelhantes em pacientes TTV positivos e pacientes TTV negativos. Uma arvore filogend- tica foi construida e mostrou isolados do TTV dos genOtipos 1, 2, 3 e 4. Em conclusk, a infeccao pelo TTV foi mais freq0ente entre doadores de sangue do que em pacientes corn hepatite aguda A ou B, em Salvador- Bahia. 0 TTV nao aumentou a gravidade da atividade necroinflamatdria dos pacientes com hepatite aguda A ou B. Atraves de analise filogendtica foram encontrados isolados do TTV dos genotipos 1, 2, 3 e 4 na popu- lack estudada.
dc.descriptionAlves de Queiroz Family Fund for Research.
dc.descriptionThe aim of this study was to evaluate the prevalence of TTV in patients with acute hepatitis A and B, and to genotype TTV isolates by phylogenetic analysis. The authors evaluated sera of 82 patients who had acute hepatitis A (N = 40) and B (N = 42), and of 71 blood donors. TTV was detected by nested-PCR assay and phylogenetic analysis was performed using the neighbor-joining method. TTV was detected in 23% of pa- tients with acute hepatitis and in 31% of donors. Mean aminotransferase levels were similar in patients who were TTV positive and TTV negative. A phylogenetic tree was drawn that showed TTV isolates of genotype 1, 2, 3, and 4. In conclusion, TTV infection is more frequent among blood donors than among patients with acute hepatitis A or B in Salvador-Bahia. TTV does not appear to increase the severity of necroinflammatory activity of acute hepatitis A or B. Using phylogenetic analysis TTV isolates of genotype 1, 2, 3, and 4 were encountered in the study population.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHepatite aguda
dc.subjectTTV
dc.subjectGenótipo
dc.subjectAnálise filogenética
dc.subjectAcute hepatitis
dc.subjectTTV
dc.subjectGenotype
dc.subjectPhylogenetic analysis
dc.titlePrevalence of TTV in blood donors and patients with acute viral hepatitis and genotyping by phylogenetic analysis
dc.typeArticle


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