Article
Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon
Registro en:
TASHI, Tenzin et al. Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon. PLoS Negl Trop Dis., v. 16, n. 11, e0010773, p. 1 - 16, Nov. 2022.
1935-2727
10.1371/journal.pntd.0010773
Autor
Tashi, Tenzin
Upadhye, Aditi
Kundu, Prasun
Wu, Chunxiang
Menant, Sébastien
Soares, Roberta Reis
Ferreira, Marcelo U.
Longley, Rhea J.
Mueller, Ivo
Q. Hoang, Quyen
Tham, Wai-Hong
Rayner, Julian C.
Scopel, Kézia KG
Lima Junior, Josué C.
Tran, Tuan M.
Resumen
Background
To make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium
vivax is urgently needed. Evaluating the kinetics of natural antibody responses to vaccine
candidate antigens after acute vivax malaria can inform the design of serological
markers of exposure and vaccines.
Methodology/Principal findings
The responses of IgG antibodies to 9 P. vivax vaccine candidate antigens were evaluated in
longitudinal serum samples from Brazilian individuals collected at the time of acute vivax
malaria and 30, 60, and 180 days afterwards. Antigen-specific IgG correlations, seroprevalence,
and half-lives were determined for each antigen using the longitudinal data. Antibody
reactivities against Pv41 and PVX_081550 strongly correlated with each other at each of
the four time points. The analysis identified robust responses in terms of magnitude and seroprevalence against Pv41 and PvGAMA at 30 and 60 days. Among the 8 P. vivax antigens demonstrating >50% seropositivity across all individuals, antibodies specific to
PVX_081550 had the longest half-life (100 days; 95% CI, 83–130 days), followed by
PvRBP2b (91 days; 95% CI, 76–110 days) and Pv12 (82 days; 95% CI, 64–110 days).
Materias
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