Article
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting
Registro en:
DE ANDRADE LIMA, E. et al. Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting. Acta Dermato-Venereologica, v. 91, n. 6, p. 694–697, out. 2011.
1651-2057
10.2340/00015555-1151
Autor
Lima, Emerson de Andrade
Lima, Mariana de Andrade
Lorena, Virgínia M. Barros de
Gomes, Yara de Miranda
Lupi, Omar
Benard, Gil
Resumen
Fundação de Amparo a Pesquisa de São Paulo número de concessão 2008 / 57608-2 Screening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-γ release assay (IGRA) compared with the tuberculin skin test, there is a debate about whether this holds true in tuberculosis endemic areas. The performance of an IGRA kit T-SPOT.TB was evaluated in 33 moderate-to-severe untreated psoriasis patients and, as controls, 30 patients with common dermatological diseases at a tuberculosis highly endemic setting. The frequency of positive tuberculin skin test responses and induration size in controls were higher than in psoriasis patients (53% vs. 18% and 9.3 ± 1.4 vs. 2.6 ± 0.7 mm, respectively, p < 0.001). In contrast, the frequency of positive response and mean number of spots elicited with the T-SPOT.TB test were not significantly different between patients and controls (47% vs. 43% and 14.7 ± 3.2 vs. 20.5 ± 3.1 spots/well, respectively). The two tests presented good agreement in the control, but not the psoriasis group (κ values of 0.625 and 0.375, respectively). Thus, in a highly tuberculosis-endemic setting the T-SPOT.TB test was superior to the tuberculin skin test in diagnosing latent tuberculosis infection in psoriasis, probably because the immune dysregulation of psoriasis shows a lower interference in the in vitro test.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
How to categorize individuals on the basis of underlying attitudes? A discussion on latent variables, latent classes and hybrid choice models
Bahamonde Birke, F. J.; Ortúzar Salas, Juan de Dios (2021) -
Latent indexation and exchange rate passthrough
Fiorencio, Antonio; Moreira, Ajax Reynaldo Bello -
Heterogeneity in Involvement in School Bullying: A Latent Classes Analysis
Mellado, Carlos; Mendez-Bustos, Pablo