Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition

dc.creatorPeixoto, Christina Alves
dc.creatorNunes, Ana Karolina Santana
dc.creatorGarcia-Osta, Ana
dc.date2017-09-12T19:35:23Z
dc.date2017-09-12T19:35:23Z
dc.date2015
dc.date.accessioned2023-09-26T22:48:41Z
dc.date.available2023-09-26T22:48:41Z
dc.identifierPEIXOTO, C. A.; NUNES, A. K. S.; GARCIA-OSTA, A. Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition. Mediators of Inflammation, v. 2015, p. 940207, 2015
dc.identifier1466-1861
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20991
dc.identifier10.1155/2015/940207
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883476
dc.descriptionPhosphodiesterase type 5 inhibitors (PDE5-Is) have recently emerged as a potential therapeutic strategy for neuroinflammatory, neurodegenerative, and memory loss diseases. Mechanistically, PDE5-Is produce an anti-inflammatory and neuroprotection effect by increasing expression of nitric oxide synthases and accumulation of cGMP and activating protein kinase G (PKG), the signaling pathway of which is thought to play an important role in the development of several neurodiseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The aim of this paper was to review present knowledge of the signaling pathways that underlie the use of PDE5-Is in neuroinflammation, neurogenesis, learning, and memory.
dc.formatapplication/pdf
dc.languagepor
dc.rightsopen access
dc.subjectCognição
dc.subjectDegeneração Neural
dc.subjectNeuroimunomodulação
dc.subjectInibidores da Fosfodiesterase 5
dc.subjectCognition
dc.subjectNerve Degeneration
dc.subjectNeuroimmunomodulation
dc.subjectPhosphodiesterase 5 Inhibitors
dc.subjectAnimals
dc.subjectBlood-Brain Barrier
dc.subjectHumans
dc.subjectMice
dc.subjectNeuroglia
dc.subjectNeurogenesis
dc.subjectNeuroprotective Agents
dc.subjectNucleotides, Cyclic
dc.subjectCognição
dc.subjectDegeneração Neural
dc.subjectNeuroimunomodulação
dc.subjectInibidores da Fosfodiesterase 5
dc.subjectAnimais
dc.subjectBarreira Hematoencefálica
dc.subjectHumanos
dc.subjectCamundongos
dc.subjectNeurogênese
dc.subjectNeuroglia
dc.subjectFármacos Neuroprotetores
dc.subjectNucleotídeos Cíclicos
dc.titlePhosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition
dc.typeArticle


Este ítem pertenece a la siguiente institución