Interaction of stromal and microvascular components in keratocystic odontogenic tumors

dc.creatorSousa Neto, Ernesto Santos
dc.creatorCangussu, Maria Cristina Teixeira
dc.creatorGurgel, Clarissa Araújo
dc.creatorGuimarães, Vanessa Sousa Nazaré
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorXavier, Flávia Caló Aquino
dc.creatorCury, Patrícia Ramos
dc.creatorCarneiro Júnior, Braúlio
dc.creatorLeonardi, Rosalia
dc.creatorSantos, Jean Nunes Dos
dc.date2017-03-21T13:08:08Z
dc.date2017-03-21T13:08:08Z
dc.date2016
dc.date.accessioned2023-09-26T22:46:34Z
dc.date.available2023-09-26T22:46:34Z
dc.identifierSOUZA NETO, E. S. et al. Interaction of stromal and microvascular components in keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 45, p. 557–564, 2016.
dc.identifier0904-2512
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18093
dc.identifier10.1111/jop.12400
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8883055
dc.descriptionLittle is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MCs), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOTs). MATERIAL AND METHODS: Thirty cases of KCOTs were included and analyzed by immunohistochemistry for mast cell tryptase, a-SMA, CD34, CD163, and D240. For comparative purpose, 15 radicular cysts (CRs) and 7 pericoronal follicles (PFs) were included. RESULTS: There was an increase in MCs for RCs and this difference was significant when they were compared to KCOTS and PFs. A significant increase in the density of MFs was observed for KCOTs when compared to RCs and PFs (P = 0.00). No significant difference in CD163- positive macrophages (P = 0.084) and CD34-positive vessels (P = 0.244) densities was observed between KCOTs, RCs, and PFs, although KCOTs showed a higher density of all proteins. Significant difference in lymphatic vessel density was observed for KCOTs when compared to RCs and PFs (P = 0.00). Positive correlation was observed between mast cell tryptase and CD34 in KCOTs (P = 0.025). CONCLUSIONS: A significant interaction between the MC population and CD34-positive vessels in KCOTs supported the hypothesis that MCs and blood vessels contribute to the stromal scaffold of KCOT
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsopen access
dc.subjectAngiogenese
dc.subjectCélulas
dc.subjectQueratocisto
dc.subjectLinfangiogenese
dc.subjectMacrófagos
dc.subjectMiofibroblastos
dc.subjectAngiogenesis
dc.subjectCells
dc.subjectKeratocyst
dc.subjectLymphangiogenesis
dc.subjectMacrophages
dc.subjectMyofibroblasts
dc.titleInteraction of stromal and microvascular components in keratocystic odontogenic tumors
dc.typeArticle


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