Article
Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome
Registro en:
CONDE, Fernando de Paiva et al. Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome. PLoS Neglected Tropical Diseases, v. 13, n. 12, p. 1-15, Dec. 2019.
1932-2727
10.1371/journal.pntd.0007915
1935-2735
Autor
Conte, Fernando de Paiva
Tinoco, Bianca Corrêa
Chaves, Thiago Santos
Oliveira, Renata Carvalho de
Mansur, Janaina Figueira
Mohana-Borges, Ronaldo
Lemos, Elba Regina S.
Neves, Patricia Cristina da Costa
Silva, Rodrigo Nunes Rodrigues da
Resumen
Orthohantavirus infection is a neglected global health problem affecting approximately 200,000 people/year, spread by rodent hosts and associated to fatal human diseases, such as hemorrhagic fever with renal syndrome (HFRS) and orthohantavirus cardiopulmonary syndrome (HCPS). Circulation of HFRS-associated orthohantaviruses, such as Seoul, Gou, Amur, Dobrava and Hantaan, are supposed to be restricted to Eurasian countries even though their hosts can be a worldwide distribution. Few confirmed HFRS orthohantavirus infections in humans have been reported in American countries, but due to lower medical awareness of the symptoms of this zoonosis, it could be associated to viral underreporting or to misdiagnosis with several tropical hemorrhagic diseases. Serological evidence of orthohantavirus infections, using enzyme-linked immunosorbent assay for the presence of immunoglobulin M and G against recombinant nucleoprotein protein, remains as an essential assay for viral surveillance. In this study, we aimed to identify in silico immunogenic B-cell linear epitopes present on orthohantavirus nucleoprotein that are exclusive to HFRS-related species.