Lipid Droplet, a Key Player in Host-Parasite Interactions

dc.creatorVallochi, Adriana Lima
dc.creatorTeixeira, Livia
dc.creatorOliveira, Karina da Silva
dc.creatorMonteiro, Clarissa Menezes Maya
dc.creatorBozza, Patrícia T.
dc.date2018-09-27T14:52:58Z
dc.date2018-09-27T14:52:58Z
dc.date2018
dc.date.accessioned2023-09-26T22:43:57Z
dc.date.available2023-09-26T22:43:57Z
dc.identifierVALLOCHI, Adriana Lima; et al. Lipid Droplet, a Key Player in Host-Parasite interactions. Frontiers in Immunology, v.9, Article 1022, 18p, May 2018.
dc.identifier1664-3224
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/29103
dc.identifier10.3389/fimmu.2018.01022
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8882504
dc.descriptionLipid droplets (lipid bodies, LDs) are dynamic organelles that have important roles in regulating lipid metabolism, energy homeostasis, cell signaling, membrane trafficking, and inflammation. LD biogenesis, composition, and functions are highly regulated and may vary according to the stimuli, cell type, activation state, and inflammatory environment. Increased cytoplasmic LDs are frequently observed in leukocytes and other cells in a number of infectious diseases. Accumulating evidence reveals LDs participation in fundamental mechanisms of host-pathogen interactions, including cell signaling and immunity. LDs are sources of eicosanoid production, and may participate in different aspects of innate signaling and antigen presentation. In addition, intracellular pathogens evolved mechanisms to subvert host metabolism and may use host LDs, as ways of immune evasion and nutrients source. Here, we review mechanisms of LDs biogenesis and their contributions to the infection progress, and discuss the latest discoveries on mechanisms and pathways involving LDs roles as regulators of the immune response to protozoan infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectgotículas lipídicas
dc.subjectcorpos lipídicos
dc.subjectParasitos
dc.subjectpatógeno intracelular
dc.subjecteicosanóides
dc.subjectInflamação
dc.subjectresposta imune
dc.subjectlipid droplets
dc.subjectlipid bodies
dc.subjectparasite
dc.subjectintracellular pathogen
dc.subjecteicosanoids
dc.subjectinflammation
dc.subjectimmune response
dc.titleLipid Droplet, a Key Player in Host-Parasite Interactions
dc.typeArticle


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