Article
Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population
Registro en:
COSTA, R. dos S. et al. Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population. Annals of Allergy, Asthma and Immunology, p.1-6, 2017.
1081-1206
10.1016/j.anai.2017.01.028
Autor
Costa, Ryan Dos Santos
Figueiredo, Camila Alexandrina
Barreto, Maurício Lima
Neves, Neuza Maria Alcântara
Rodrigues, Laura Cunha
Cruz, Alvaro A
Vergara, Candelaria
Rafaels, Nicholas
Foster, Cassandra
Potee, Joseph
Campbell, Monica
Mathias, Rasika A
Barnes, Kathleen C
Resumen
Wellcome Trust, the HCPC Latin America Excellence Centre Programme (072405/Z/03/Z), and the Brazilian agency Conselho Nacional de Desenvolvimento Científico e TecnológicoeCNPq Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. The role of TGF- β 1 single-nucleotide polymorphisms (SNPs) in allergic disease remains inconclusive. Objective: To evaluate the effects of genetic variations in the TGF-b1 on allergy and helminths infections in
children.
Methods: We tested for association among 4 TGF-b1 SNPs and allergic asthma, specific IgE, skin prick test
result, and IL-10 production in 1,335 Brazilians. In addition, we analyzed the association with markers of
helminth infection (parasite burden, anti-Ascaris IgE, and worm specific IgG4). The polymorphisms were
genotyped using Taq Man probes.
Results: We found an association between rs1800470 (C allele) and atopic wheezing (odds ratio [OR], 0.60;
95% confidence interval [CI], 0.37e0.95) and markers of allergy (OR, 0.41; 95% CI, 0.22e0.79). In contrast, a
positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85;
P ¼ .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001). This haplotype was also associated with
increased IL-10 production (b ¼ 50.7; P < .001).
Conclusion: Individuals with TGF-b1 polymorphisms have an increased susceptibility to helminth infections
and a lower risk of developing allergy. These studies suggest that immune modulation of allergic disease
results not only from environmental factors but also from genetic susceptibility and IL-10 production