Article
Cysteine proteases during larval migration and development of helminths in their final host
Registro en:
GROTE, Alexandra et al. Cysteine proteases during larval migration and development of helminths in their final host. PLoS Negl. Trop Dis., v. 12, n. 8, p. 1-8, Aug. 2018.
1935-2727
10.1371/journal.pntd.0005919
1935-2735
Autor
Grote, Alexandra
Caffrey, Conor R.
Rebello, Karina M.
Smith, David
Dalton, John P.
Lustigman, Sara
Resumen
Neglected tropical diseases caused by metazoan parasites are major public health concerns, and therefore, new methods for their control and elimination are needed. Research over the last 25 years has revealed the vital contribution of cysteine proteases to invasion of and migration by (larval) helminth parasites through host tissues, in addition to their roles in embryogenesis, molting, egg hatching, and yolk degradation. Their central function to maintaining parasite survival in the host has made them prime intervention targets for novel drugs and vaccines. This review focuses on those helminth cysteine proteases that have been functionally characterized during the varied early stages of development in the human host and embryogenesis.