CD3(+)CD4(neg)CD8(neg) (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a(+) cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis

dc.creatorFerraz, Raquel
dc.creatorCunha, Clarissa F.
dc.creatorPimentel, Maria Inês F.
dc.creatorLyra, Marcelo R.
dc.creatorSilva, Tatiana Pereira da
dc.creatorSchubach, Armando O.
dc.creatorCruz, Alda Maria da
dc.creatorBertho, Álvaro Luiz
dc.date2017-11-21T14:09:14Z
dc.date2017-11-21T14:09:14Z
dc.date2017
dc.date.accessioned2023-09-26T22:37:48Z
dc.date.available2023-09-26T22:37:48Z
dc.identifierFERRAZ, Raquel; et al.CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Parasites & Vectors, v.10:219, 12p, 2017.
dc.identifier1756-3305
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23285
dc.identifier10.1186/s13071-017-2152-2
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8881228
dc.descriptionCutaneous leishmaniasis (CL) is caused by Leishmania (Viannia) braziliensis, which infects dermal macrophages and dendritic cells, causing an intense immune-mediated-tissue inflammation and a skin ulcer with elevated borders that can heal spontaneously or after antimonial therapy. The resolution of lesions depends on an adaptive immune response, and cytotoxic cells seem to have a fundamental role in this process. The aim of this study is to better understand the role of cytotoxicity mediated mechanisms that occur during the immune response in the CL lesion milieu, considering distinct cytotoxic-related CD107a(+) cells, such as CD8(+), CD4(+), CD4(neg) CD8(neg) (double-negative, DN) and CD4(+)CD8(+) (double-positive, DP) T lymphocytes, as well as NK and NKT cells.
dc.formatapplication/pdf
dc.languageeng
dc.publisherBioMed Central
dc.rightsopen access
dc.subjectCitometria de fluxo
dc.subjectCitotoxicidade
dc.subjectLinfocitos T de duplo negativo
dc.subjectLesão
dc.subjectLeishmaniose cutânea humana
dc.subjectCélulas T Matadoras Naturais
dc.subjectLeishmania braziliensis
dc.subjectFlow cytometry
dc.subjectCytotoxicity
dc.subjectCD107a
dc.subjectDouble-negative T lymphocytes
dc.subjectNKT cells
dc.subjectLesion
dc.subjectHuman cutaneous leishmaniasis
dc.subjectLeishmania (Viannia) braziliensis
dc.titleCD3(+)CD4(neg)CD8(neg) (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a(+) cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis
dc.typeArticle


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