Altered composition and functional profile of high-density lipoprotein in leprosy patients

dc.creatorLemes, Robertha Mariana R.
dc.creatorSilva, Carlos Adriano de M. e
dc.creatorMarques, Maria Ângela de M.
dc.creatorAtella, Georgia C.
dc.creatorNery, José Augusto da C.
dc.creatorNogueira, Maria Renata S.
dc.creatorRosa, Patricia S.
dc.creatorSoares, Cléverson T.
dc.creatorPrithwiraj, De
dc.creatorChatterjee, Delphi
dc.creatorPessolani, Maria Cristina V.
dc.creatorMacedo, Cristiana S. de
dc.date2020-12-22T19:12:33Z
dc.date2020-12-22T19:12:33Z
dc.date2020
dc.date.accessioned2023-09-26T22:36:34Z
dc.date.available2023-09-26T22:36:34Z
dc.identifierLEMES, Robertha Mariana R. et al. Altered composition and functional profile of high-density lipoprotein in leprosy patients. PLoS Neglected Tropical Diseases, v. 14, n. 3, p. 1-23, Mar. 2020.
dc.identifier1935-2727
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45081
dc.identifier10.1371/journal.pntd.0008138
dc.identifier1935-2735
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880960
dc.descriptionThe changes in host lipid metabolism during leprosy have been correlated to fatty acid alterations in serum and with high-density lipoprotein (HDL) dysfunctionality. This is most evident in multibacillary leprosy patients (Mb), who present an accumulation of host lipids in Schwann cells and macrophages. This accumulation in host peripheral tissues should be withdrawn by HDL, but it is unclear why this lipoprotein from Mb patients loses this function. To investigate HDL metabolism changes during the course of leprosy, HDL composition and functionality of Mb, Pb patients (paucibacillary) pre- or post-multidrug therapy (MDT) and HC (healthy controls) were analyzed. Mb pre-MDT patients presented lower levels of HDL-cholesterol compared to HC. Moreover, Ultra Performance Liquid Chromatography-Mass Spectrometry lipidomics of HDL showed an altered lipid profile of Mb pre-MDT compared to HC and Pb patients. In functional tests, HDL from Mb pre-MDT patients showed impaired anti-inflammatory and anti-oxidative stress activities and a lower cholesterol acceptor capacity compared to other groups. Mb pre-MDT showed lower concentrations of ApoA-I (apolipoprotein A-I), the major HDL protein, when compared to HC, with a post-MDT recovery. Changes in ApoA-I expression could also be observed in M. leprae-infected hepatic cells. The presence of bacilli in the liver of a Mb patient, along with cell damage, indicated hepatic involvement during leprosy, which may reflect on ApoA-I expression. Together, altered compositional and functional profiles observed on HDL of Mb patients can explain metabolic and physiological changes observed in Mb leprosy, contributing to a better understanding of its pathogenesis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectHanseníase
dc.subjectPacientes
dc.subjectComposição alterada
dc.subjectPerfil funcional
dc.subjectLipoproteína de alta densidade
dc.subjectLeprosy
dc.subjectAltered composition
dc.subjectFunctional profile
dc.subjectHigh-density lipoprotein
dc.subjectPatients
dc.titleAltered composition and functional profile of high-density lipoprotein in leprosy patients
dc.typeArticle


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