Article
Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil
Registro en:
DELATORRE, Edson Oliveira; et al. Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil. Aids Research and Human Retroviruses, v.28, n.10, p.1369-1372, 2012.
0889-2229
10.1089/aid.2011.0381
1931-8405
Autor
Delatorre, Edson Oliveira
Bello, Gonzalo
Silva, Walter de Araujo Eyer
Chequer-Fernandez, Saada L.
Morgado, Mariza G.
Fernandez, José Carlos Couto
Resumen
HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from
patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To
trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and
another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there
have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four
phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and
Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated
throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous
epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the
early detection of newly emerging viral lineages. 2030-01-01