Article
Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis
Registro en:
ENNES-VIDAL, Vitor et al. Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, e190147, 12p, 2019.
0074-0276
10.1590/0074-02760190147
1678-8060
Autor
Ennes-Vidal, Vítor
Vitório, Bianca da Silva
Menna-Barreto, Rubem F. S.
Pitaluga, André Nóbrega
Silva, Silvia Amaral Gonçalves da
Branquinha, Marta Helena
Santos, André Luis Souza
d'Avila-Levy, Claudia Masini
Resumen
Calpains are proteins belonging to the multi-gene family of calcium-dependent cysteine peptidases that undergo tight on/off regulation, and uncontrolled proteolysis of calpains is associated with severe human pathologies. Calpain orthologues are expanded and diversified in the trypanosomatids genome.