Article
Comparative efficacies of two antimony regimens to treat Leishmania braziliensis-induced cutaneous Leishmaniasis in rhesus macaques (Macaca mulatta)
Registro en:
GRIMALDI JR., G. et al. Comparative Efficacies of Two Antimony Regimens To Treat Leishmania braziliensis-Induced Cutaneous Leishmaniasis in Rhesus Macaques (Macaca mulatta). Antimicrobial Agents and Chemotherapy, v.54, n.1, p.502-505, Jan.2010.
0066-4804
10.1128/AAC.00858-09
1098-6596
Autor
Grimaldi, G.
Porrozzi, R.
Friedrich, K.
Teva, A.
Marchevsky, R. S.
Vieira, F.
Miekeley, N.
Paumgartten, F. J. R.
Resumen
This study compared the efficacies of two N-methylglucomine antimoniate (MA) dose regimens for treating macaques with Leishmania braziliensis-induced chronic skin disease. Whereas all animals treated with the full dose (20 mg MA/kg/day) were cured, 50% of the monkeys receiving a low-dose regimen (5 mg MA/kg/day) relapsed. The antimony concentrations in macaque plasma and tissue samples were greater in the full-dose group than in that receiving a subtherapeutic MA regimen. Our data also suggest the presence of drug-induced hepatic pathology.