Article
Synthesis and evaluation of cytotoxic activity of arylfurans
Registro en:
OLIVEIRA, Renata Barbosa de, et al. Synthesis and evaluation of cytotoxic activity of arylfurans. Eur. j. med. chem. 2006; 41(6): 756–760
0223-5234
org/10.1016/j.ejmech.2006.03.010
Autor
Oliveira, Renata Barbosa de
Fagundes, Elaine Maria de Souza
Siqueira, Helen A. J.
Leite, Rodrigo Souza
Donnici, Claudio Luis
Zani, Carlos Leomar
Resumen
A series of 2-aryl and 2,5-diarylfurans were synthesized and evaluated for their in vitro cytotoxicity against human cancer cells lines and on the proliferation of human peripheral blood mononuclear cells (PBMC) stimulated with phytohemaglutinin (PHA). Three compounds were found to present significant activity against the cancer cell lines without affecting the lymphocyte proliferation in PBMCs, indicating low toxicity to normal cells.