Single dose toxicity study of beta-myrcene, a natural analgesic substance

dc.creatorPaumgartten, Francisco José Roma
dc.creatorDelgado, Isabella Fernandes
dc.creatorAlves, Eloisa Nunes
dc.creatorNogueira, Ana Cristina Martins de Almeida
dc.creatorPresgrave, Rosaura de Farias
dc.creatorNeubert, Diether
dc.date2015-07-15T11:42:46Z
dc.date2015-07-15T11:42:46Z
dc.date1990
dc.date.accessioned2023-09-26T22:25:22Z
dc.date.available2023-09-26T22:25:22Z
dc.identifierPAUMGARTTEN, F. J. R. et al. Single dose toxicity study of beta-myrcene, a natural analgesic substance. Braz. J. Med. Biol. Res., São Paulo, v. 23, n. 9, p. 873-877, 1990.
dc.identifier0100-879X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/11357
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8879005
dc.descriptionThe present study was undertaken to provide data on acute toxicity of beta-myrcene, a peripheral analgesic substance found in the essential oils of several plants. Although myrcene has long been used in perfumes and as a food additive, there is almost no information on its toxicological hazards. The acute oral toxicity of myrcene was low in rodents, with approximate lethal doses (ALD) of 5.06 g/kg body weight for mice and greater than 11.39 g/kg body weight for rats. Necropsy data did not reveal any relevant alteration in rats but histopathology findings in mice suggested that the liver and stomach may be target organs for myrcene toxicity after oral administration. Myrcene is highly irritant to the peritoneum, and deaths after intraperitoneal injection of this monoterpene in rats (ALD 5.06 g/kg body weight) and in mice (ALD 2.25 g/kg body weight) were probably due to drug-induced chemical peritonitis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.rightsopen access
dc.subjectMirceno
dc.subjectMonoterpenos
dc.subjectÓleos Voláteis
dc.subjectAnalgésicos
dc.subjectToxicidade Aguda
dc.subjectAditivos Alimentares
dc.subjectMyrcene
dc.subjectMonoterpenes
dc.subjectOils, Volatile
dc.subjectAnalgesics
dc.subjectAcute Toxicity
dc.subjectFood Additives
dc.subjectMonoterpenos
dc.subjectÓleos Voláteis
dc.subjectAnalgésicos
dc.subjectToxicidade Aguda
dc.subjectAditivos Alimentares
dc.titleSingle dose toxicity study of beta-myrcene, a natural analgesic substance
dc.typeArticle


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