Article
Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis
Registro en:
GIUNCHETTI, Rodolfo Cordeiro et al. Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis. Research in Veterinary Science, v. 84, n. 2, p. 269-277, 2008. doi: 10.1016/j.rvsc.2007.04.020.
0034-5288
10.1016/j.rvsc.2007.04.020
Autor
Giunchetti, Rodolfo Cordeiro
Mayrink, Wilson
Carneiro, Cláudia Martins
Oliveira, Rodrigo Corrêa de
Martins Filho, Olindo Assis
Marques, Marcos José
Tafuri, Washington Luiz
Reis, Alexandre Barbosa
Resumen
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO The immunopathological evaluation of the hepatic compartment associated with parasitism and biochemical findings are essential for understanding the genesis of hepatomegaly in canine visceral leishmaniasis (CVL). Three clinical groups of dogs naturally infected with Leishmania chagasi [i.e., asymptomatic (AD, n = 12), oligosymptomatic (OD, n = 12) and symptomatic (SD, n = 17)] were assessed and compared with a group of non-infected dogs (NID, n = 11). Intense reaction of the Kupffer cells, capsule and portal inflammation, and the presence of intralobular granulomas, were observed in the different clinical groups. Dogs in the SD group presented a higher frequency of parasitism compared with the AD group. Inflammatory alterations were more intense in the SD group and were associated with parasitism. Our results indicated an association between histological liver changes and the progression of biochemical alterations according to progression of clinical forms of CVL, and the direct relationship between clinical symptoms and frequency of hepatic parasitism.