Article
The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies
Registro en:
YU, Bin et al. The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology, v. 188, n. 6, p. 991-1012, 2019.
0002-9262
10.1093/aje/kwz028
Autor
Yu, Bing
Zanetti, Krista A.
Temprosa, Marinella
Albanes, Demetrius
Appel, Nathan
Barrera, Clara Barrios
Ben-Shlomo, Yoav
Boerwinkle, Eric
Casas, Juan P.
Clish, Clary
Dale, Caroline
Dehghan, Abbas
Derkach, Andriy
Eliassen, A Heather
Elliott, Paul
Fahy, Eoin
Gieger, Christian
Gunter, Marc J.
Harada, Sei
Harris, Tamara
Herr, Deron R.
Herrington, David
Hirschhorn, Joel N
Hoover, Elise
Hsing, Ann W.
Johansson, Mattias
Kelly, Rachel S
Khoo, Chin Meng
Kivimäki, Mika
Kristal, Bruce S.
Langenberg, Claudia
Lasky-Su, Jessica
Lawlor, Deborah A.
Lotta, Luca A
Mangino, Massimo
Marchand, Loïc Le
Mathé, Ewy
Matthews, Charles E.
Menni, Cristina
Mucci, Lorelei A.
Murphy, Rachel
Oresic, Matej
Orwoll, Eric
Ose, Jennifer
Pereira, Alexandre C.
Playdon, Mary C.
Poston, Lucilla
Price, Jackie
Qi, Qibin
Rexrode, Kathryn
Risch, Adam
Sampson, Joshua
Seow, Wei Jie
Sesso, Howard D.
Shah, Svati H.
Shu, Xiao-Ou
Smith, Gordon C. S.
Sovio, Ulla
Stevens Victoria L.
Stolzenberg-Solomon, Rachael
Takebayashi, Toru
Tillin, Therese
Travis, Ruth
Tzoulaki, Ioanna
Ulrich, Cornelia M.
Vasan, Ramachandran S.
Verma, Mukesh
Wang, Ying
Wareham, Nick J.
Wong, Andrew
Younes, Naji
Zhao, Hua
Zheng, Wei
Moore, Steven C.
Resumen
Alexandre C. Pereira. Fundação Oswaldo Cruz. Instituto de Pesquisas Rene Rachou. Belo Horizonte, MG, Brasil. The Consortium of Metabolomics Studies (COMETS) was established in 2014 to facilitate large-scale collaborative research on the human metabolome and its relationship with disease etiology, diagnosis, and prognosis. COMETS comprised 47 cohorts from Asia, Europe, North America and South America that together include 137, 000+ participants with blood metabolomics data on samples collected from 1985-2017. Metabolomics data were provided by 17 different platforms with the most frequently used labs being Metabolon Inc. (14 cohorts), the Broad Institute (15 cohorts), and Nightingale Health (11 cohorts). Participants were followed for a median 23 years for health outcomes, including death, cancer, cardiovascular disease, diabetes and others. Available exposure-related data include common clinical measurements, behavioral factors, as well as genome-wide genotype data. Two feasibility studies were conducted to evaluate the comparability of metabolomics platforms used by COMETS cohorts. The first study showed that the overlap between any two different laboratories ranged from 6 to 121 metabolites at five leading laboratories. The second study showed that the median Spearman correlation comparing 111 overlapping metabolites captured by Metabolon and the Broad Institute was 0.79 (interquartile range: 0.56-0.89). 2025-01-01