Article
Estudo sobre a relação entre testoterona/progesterone e o surgimento de comportamento agressivo de camundongos machos da linhagem Swiss Webster
Total testosterone/progesterone rate and appearance of spontaneous aggressive behavior in male Swiss Webster mice
Registro en:
DEMARQUE, Kelly Cristina et al. Total testosterone/progesterone rate and appearance of spontaneous aggressive behavior in male swiss webster mice. RESBCAL, v.2, n.3, p. 206-216, 2013
2238-1589
Autor
Demarque, Kelly Cristina
Rangel, Janaína Alves
Kuzel, Maria Alice do Amaral
Rodriques, Frederico Villas Boas
Oliveira, Fernanda da Silva
Alvarenga, Tathiana A.
Andersen, Monica L.
Tufik, Sergio Batista
Silva, Wanderson
Gameiro, Lucas dos Santos
Oliveira, Gabriel Melo de
Resumen
Violence is a serious public health problem and has a high impact on the quality of life of
individuals across societies. Evolutionary, genetic, environmental, and cultural factors are
closely interconnected as morbid causes. Animal models can be an important tool in the
study of aggression. Regrouped Swiss Webster mice were selected based on mobility
profile (Hypo, Normal; Hyper), which was defined by the tail suspension test. Our results
demonstrate that Hyper mice (anxiety-like behavior) were more aggressive and violent
than the other two categories, indicated by a pattern of aggressive behavior with a score
4+ in relation to score 1+ of Normal category. Hyper group, showed a decrease in total
testosterone levels (-32.5% in relation to Norm group) and an increase in progesterone
levels (+57.6% compared with the Norm group). We also observed a decrease in the
weight of the testicles, the seminiferous tubules, Leydig and diploid spermatogenic
cells number in hyper aggressive animals. Together, the results indicate an association
between testosterone/progesterone and the appearance of highly aggressive behavior
in male Swiss Webster mice. CEUA/FIOCRUZ, #LW-5/12.