Article
Thymic microenvironmental alterations in experimentally induced diabetes
Registro en:
NAGIB, Patrícia R. A. et al. Thymic microenvironmental alterations in experimentally induced diabetes. Immunobiology, v.215, p.971-979, 2010
0171-2985
10.1016/j.imbio.2010.02.001
1878-3279
Autor
Nagib, Patrícia R. A.
Gameiro, Jacy
Silva, Luiz Guilherme Stivanin
Arruda, Maria Sueli Parreira de
Verde, Déa Maria Serra Villa
Savino, Wilson
Verinaud, Liana
Resumen
Little is known about the immunologic consequences from endocrine changes observed in diabetes. Since a preserved thymic microenvironment is of critical importance for the T cell development and maturation, we have examined the thymus from alloxan-diabetic mice. An intense thymic atrophy accompanied by changes in histological pattern and in thymocyte subpopulations were observed in diabetic mice. Laminin and fibronectin, which are closely associated with thymocytes maturation, were evaluated, but, only laminin presented an altered distribution and density in thymuses from diabetes group. the expression of fibronectin and laminin receptors was found to be decreased in diabetic mice. There was also intense decrease in the expression of two important chemokines for thymus, CCL25 and CXCL12, and in the CCR9 (CCL25 receptor), but the expression of CXCR4 (CXCL12 receptor) did not drop on cells. However, no significant difference was observed in the in vitro thymocytes migratory capacity from diabetic mice. The results show significant alterations in thymus microenvironment in diabetes and offer insights for studies involving endocrine influences on lymphatic organs and T cell maturation. 2030-01-01