Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni

dc.creatorMelo, Cristiane Moutinho Lagos de
dc.creatorLima, Amanda Lucena Rosendo de
dc.creatorBeltrão, Eduardo Isidoro Carneiro
dc.creatorCavalcanti, Carmelita C Bezerra
dc.creatorMelo-Júnior, Mário Ribeiro de
dc.creatorMontenegro, Silvia Maria L.
dc.creatorCoelho, Luana Cassandra B. Barroso
dc.creatorCorreia, Maria Tereza dos Santos
dc.creatorCarneiro-Leão, Ana Maria dos Anjos
dc.date2018-04-23T14:06:39Z
dc.date2018-04-23T14:06:39Z
dc.date2011
dc.date.accessioned2023-09-26T22:18:15Z
dc.date.available2023-09-26T22:18:15Z
dc.identifierMELO, C. M. L. DE et al. Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni. Acta Tropica, v. 118, n. 2, p. 152–158, maio 2011.
dc.identifier1873-6254
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/26030
dc.identifier10.1016/j.actatropica.2011.01.008
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8877566
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCratylia mollis is a natural forage plant from the Northeast of Brazil. C. mollis seed lectin (Cramoll) containing molecular forms 1 and 4 (Cramoll 1,4) has shown anti-inflammatory and wound-healing activities. This work analyzed the effect of Cramoll 1,4 on experimental schistosomiasis in mice. Experimental groups (n=15/group) were composed of female albino Swiss mice, which were subcutaneously and caudally infected with Schistosoma mansoni (BH strain, 100 cercariae/mouse) and were treated with an intraperitoneal dose after infection as follows: (1) Cramoll 1,4 (50 mg kg(-1) single dose - after 40 days of infection), (2) Cramoll 1,4 (7 mg kg(-1) daily dose - for 7 days after infection) and control (untreated mice). Mice were sacrificed 8 weeks after infection and adult worms were recovered from the portal-hepatic system. Livers were fixed in 10% (v/v) formaldehyde/0.15M NaCl and tissue sections were processed for haematoxilin and Masson's trichrome stainings. Mice infected subcutaneously harboured no or very few worms and hence the effect of Cramoll 1,4 could not be assessed. Results (P≤0.05) were obtained with Cramoll 1,4 using the two treatments, with reduction of: egg excretion (79 and 80%), adult worm recovery (71 and 79%) and liver granulomas (40 and 73.5%) in relation to control. This study showed the potential anti-helminthic activity of Cramoll 1,4 when tested against Schistosomiasis mansoni infection in mice.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectCratylia mollis
dc.subjectLectina
dc.subjectEsquistossomose
dc.subjectCramoll 1,4
dc.subjectS . mansoni
dc.subjectCratylia mollis
dc.subjectLectin
dc.subjectSchistosomiasis
dc.subjectCramoll 1,4
dc.subjectS . mansoni
dc.subjectAnimais
dc.subjectAnti-helmínticos / administração & dosagem
dc.subjectAnti-helmínticos / isolamento e purificação
dc.subjectBrasil
dc.subjectModelos de Doença Animal
dc.subjectFabaceae / química
dc.subjectFêmea
dc.subjectInjeções intraperitoneais
dc.subjectLectinas / administração & dosagem
dc.subjectLectinas / isolamento e purificação
dc.subjectFígado / parasitologia
dc.subjectFígado / patologia
dc.subjectRatos
dc.subjectContagem de Ovos Parasitas
dc.subjectVeia Porta / parasitologia
dc.subjectSchistosoma mansoni / efeitos de drogas
dc.subjectEsquistossomose mansoni / quimioterapia
dc.subjectSementes / química
dc.subjectResultado do tratamento
dc.titlePotential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni
dc.typeArticle


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