Article
Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production
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QUEIROZ , Rafaella Fortini Grenfell et al. Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production. Mem. Inst. Oswaldo Cruz, Rio de Janeiro, v. 105, n. 6, p. 818-822, Sept. 2010.
0074-0276
10.1590/S0074-02762010000600015
Autor
Queiroz, Rafaella Fortini Grenfell
Silva, Eduardo de Almeida Marques da
Testasicca, Míriam conceição de Souza
Coelho, Eduardo Antonio Ferraz
Fernandes, Ana Paula
Afonso, Luiz Carlos Crocco
Rezende, Simone Aparecida
Resumen
This study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishmania chagasiinfection. These immunogenic preparations were composed of Leishmania amazonensisor Leishmania braziliensisantigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challenged with promastigotes of L. chagasiby intravenous injection. We observed that both vaccine candidates induced a significant reduction in the parasite load of the liver, while the L. amazonensisantigenic extract also stimulated a reduction in spleen parasite load. This protection was associated with a suppression of both interleukin (IL)-10 and IL-4 cytokines by spleen cells in response to L. chagasiantigen. No change was detected in the production of IFN-γ. Our data show that these immunogenic preparations reduce the type 2 immune response leading to the control of parasite replication.
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