Article
Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder
Registro en:
CARNEIRO NETO, J. A. et al. Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder. Brazilian Journal of Infectious Diseases, v. 22, n. 2, p. 79–84, 2018.
1413-8670
10.1016/j.bjid.2017.10.009
Autor
Carneiro Neto, Jose Abraão
Santos, Silvane Braga
Orge, Gloria Orge
Tanajura, Davi
Passos, Lucia
Oliveira, Cassius José
Andrade, Rosana
Melo, Cláudio Galeno de
Barroso, Ubirajara
Carvalho Filho, Edgar Marcelino
Resumen
To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL). Methods: Case series with 10 patients with overactive bladder refractory to conservativetreatment with anticholinergic or physical therapy. They received 200Ui of onabotulinum-toxin type A intravesically and were evaluated by overactive bladder symptoms score(OABSS) and King’s Health Questionnaire.Results: The mean (SD) of the age was 52 + 14.5 years and 60% were female. All of them hadconfirmed detrusor overactivity on urodynamic study. Seven patients had HAM/TSP. Themedian and range of the OABSS was 13 (12–15) before therapy and decreased to 1.0 (0–12)on day 30 and to 03 (0–14) on day 90 (p < 0.0001). There was a significant improvement in 8 ofthe 9 domains of the King’s Health Questionnaire after the intervention. Hematuria, urinaryretention and urinary infection were the complications observed in 3 out of 10 patients. Themean time to request retreatment was 465 days.Conclusion: Onabotulinum toxin type A intravesically reduced the OABSS with last long effectand improved the quality of life of HTLV-1 infected patients with severe overactive bladder.