Article
In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06
Registro en:
REIS, Patricia Alves; et al. In vivo and in vitro antimalarial effect and toxicological evaluation of the chloroquine analogue PQUI08001/06. Parasitology Research, v.117, n.3585–3590, 2018.
0932-0113
10.1007/s00436-018-6057-6
1432-1955
Autor
Reis, Patricia Alves
Pais, Karla Ceodaro
Pereira, Monica Farah
Douradinha, Bruno
Costa, Natália Ferreira
Kaiser, Carlos Roland
Bozza, Patricia Torres
Areas, André Luiz Lisboa
Zalis, Mariano Gustavo
Ferreira, Marcelle de Lima
Souza, Marcos Vinícius Nora de
Frutuoso, Valber da Silva
Faria Neto, Hugo C. de Castro
Resumen
Antimalarial interventions mostly rely upon drugs, as chloroquine. However, plasmodial strains resistant to many drugs are constantly reported, leading to an expansion of malaria cases. Novel approaches are required to circumvent the drug resistance issue. Here, we describe the antimalarial potential of the chloroquine analogue 2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]amino] ethanol (PQUI08001/06). We observed that PQUI08001/06 treatment reduces parasitemia of both chloroquine-resistant and -sensitive strains of Plasmodium falciparum in vitro and P. berghei in vivo. Our data suggests that PQUI08001/06 is a potential antimalarial therapeutic alternative approach that could also target chloroquine-resistant plasmodial strains. 2030-01-01