Article
Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2
Registro en:
VIEIRA, Debora Ferreira Barreto; et al. Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2. Virus Review and Research, v.15, n.2, 27p, 2010.
1519-2563
2357-9323
Autor
Vieira, Debora Ferreira Barreto
Schatzmayr, Hermann Gonçalves
Takiya, Christina Maeda
Jácome, Fernanda Cunha
Silva, Manoel Enderson Vieira
Faria, Nieli Rodrigues da Costa
Nogueira, Rita Maria Ribeiro
Barth, Ortrud Monika
Resumen
Histopathological and ultrastructural aspects of liver of non-neuroadapted
BALB/c mice reinfected by the intravenous route with dengue virus serotypes 1 and 2
were presented. The hepatic tissue was processed following the standard techniques for
photonic and transmission electron microscopy. Morphological studies showed
vacuolization of hepatocytes, inflammatory cells inside sinusoidal capillaries,
enlargement of sinusoidal capillaries, foci of hemorrhage inside the interstitium,
increase of surface density of reticular fibres, increase of numerical density of
sinusoidal cells, decrease of surface density of hepatocytes, edema in the peri
centrolobular vein space and presence of phyllopods and pseudopod-like extensions in
endothelial cells. DENV particles, virus antigens and DENV RNA were observed in
mosquito cells (C6/36) inoculated with sera of the animals 72 hours post-reinfection.
The hepatic alterations observed in our experimental model were similar to those
observed in human cases of dengue hemorrhagic fever. The present study shows that
BALB/c mice reinfected with a heterologous serotype of DENV develop more severe
lesions than those observed in mice in primary infection.
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