Article
Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study
Registro en:
MENDES, R. B. et al. Glypican-3 distinguishes aggressive from non-aggressive odontogenic tumors: a preliminary study. Journal of Oral Pathology and Medicine, v. 46, p. 297–300, 2017.
0904-2512
10.1111/jop.12501
Autor
Mendes, Ramon Barreto
Dias, Rosane Borges
Figueiredo, Andreia Leal
Gurgel, Clarissa Araújo
Santana Filho, Manoel
Melo, Leonardo Araújo
Trierveiler, Marília
Cury, Patrícia Ramos
Leonardi, Rosalia
Santos, Jean Nunes DOS
Resumen
National Council for Scientific and Technological Development (CNPq) Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors. METHODS: Fifty-nine cases of tumors were divided into
aggressive odontogenic tumors (20 solid ameloblastomas,
four unicystic ameloblastoma, 28 KOTs including
five associated with Gorlin–Goltz syndrome) and nonaggressive
odontogenic tumors (five adenomatoid odontogenic
tumors and two calcifying cystic odontogenic
tumors) and analyzed for glypican-3 using immunohistochemistry.
RESULTS: Glypican-3 was observed in seven solid
ameloblastoma and eighteen keratocystic odontogenic
tumors including three of the five syndromic cases,
but there was no significant difference between syndromic
and sporadic cases (P > 0.05; Fisher’s exact Test). All
cases of unicystic ameloblastoma (n = 4), adenomatoid
odontogenic tumor (n = 5), and calcifying cystic odontogenic
tumor (n = 2) were negative.
CONCLUSIONS: This provided insights into the presence
of glypican-3 in odontogenic tumors. This protein
distinguished aggressive from non-aggressive odontogenic
tumors.