Article

The zika virus individual participant data consortium: A global initiative to estimate the effects of exposure to zika virus during pregnancy on adverse fetal, infant, and child health outcomes

Registro en:
Zika Virus Individual Participant Data Consortium. The Zika Virus Individual Participant Data Consortium: A Global Initiative to Estimate the Effects of Exposure to Zika Virus during Pregnancy on Adverse Fetal, Infant, and Child Health Outcomes. Tropical medicine and infectious disease, v. 5, n. 4, p. 1-7, 2020
2414-6366
10.3390/tropicalmed5040152
Autor
Alger, Jackeline
Ximenes, Ricardo Arraes de Alencar
Avelino-Silva, Vivian I.
Bardají, Azucena
Mojica, Carlos Hernan Becerra
Benedetti, Andrea
Teixeira, Maria de Lourdes Benamor
Bethencourt, Sarah
Aburto, Victor Hugo Borja
Brant, Fátima
Brasil, Patrícia
Brickley, Elizabeth B.
Broutet, Nathalie
Buekens, Pierre
Cafferata, María Luisa
Calvet, Guilherme
Campbell, Harlan
Carabali, Mabel
Chan, Derrick
Costa, Federico
Ferreira, Orlando da Costa
Coutinho, Conrado Milani
Cunha, Antonio Jose
Cure, Carlos
Damen, Johanna A.A.
Jong, Valentijn M.T. de
Debray, Thomas P.
DeBiasi, Roberta L.
Diaz-Martinez, Luis Alfonso
Duarte, Geraldo
Ferriol, Diana María
Ganz, Jucelia S.
Gérardin, Patrick
Gilboa, Suzanne M.
Gonzalez, Maritza
Muñiz, Concepción Grajales
Gustafson, Paul
Sanchez, Luz Angela Gutierrez
Guzmán, María G.
Hofer, Cristina
Holband, Natanael
Inwani, Irene
Jaenisch, Thomas
João, Esaú
Juliana, Amadu
Kara, Edna
Kim, Caron
Ko, Albert I.
Koopmans, Marion
LaBeaud, Angelle Desiree
Lash, Maura
Lee, Ellen H.
Leo, Yee-Sin
Levis, Brooke
Low, Nicola
Macpherson, Calum N.L.
Marbán-Castro, Elena
Mattar, Salim
Maxwell, Lauren
Mayaud, Philippe
Melo, Adriana
Menéndez, Clara
Reyes, Marcela Mercado
Montoya, María Consuelo Miranda
Miranda-Filho, Demócrito de Barros
Moons, Karel G.M.
Morales, Ivonne
Moreira, Maria Elisabeth
Mulkey, Sarah B.
Medina, José Esteban Muñoz
Mussi-Pinhata, Marisa Marcia
Natrajan, Muktha S.
Njenga, M. Kariuki
Noel, Trevor P.
Nogueira, Mauricio
Osoro, Eric
Martinez, Martha Lucia Ospina
Paladini, Marc
Passos, Saulo
Perez, Freddy
Pomar, Léo
Prata-Barbosa, Arnaldo
Reis, Mitermayer
Reveiz, Ludovic
Rodó, Carlota
Rosado, Luiza Emylce Pelá
Rosenberger, Kerstin D.
Clemente, Nuria Sanchez
Sayers, Janet L.
Silva, Antonio A.
Siqueira, Isadora C. de
Sohan, Karen
Soria-Segarra, Carmen
Soriano-Arandes, Antoni
Sousa, Patricia
Souza, João Paulo
Franch, Anna Suy
Tami, Adriana
Teixeira, Mauro
Thwin, Soe Soe
Tong, Van T.
Turchi, Marília Dalva
Martelli, Celina Maria Turchi
Valencia, Diana
Kerkhove, Maria D. Van
Araújo, Thalia Velho Barreto de
Villar, Luis Angel
Benéitez, Carmen Viñuela
Wei, Yinghui
Widdowson, Marc-Alain
Wilder-Smith, Annelies
Institución
Resumen
Patrícia Brasil; Guilherme Calvet - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. Facultad de Ciencias Médicas Universidad Nacional Autónoma de Honduras, Tegucigalpa 11101, Honduras; (J.A.), Departamento de Medicina Tropical da Universidade Federal de Pernambuco, Recife 50670-901, Brazil; (R.A.d.A.X.), Medical School São Paulo, Departamento de Molestias Infecciosas e Parasitarias University of São Paulo, São Paulo 01000, Brazil; (V.I.A.S.), Maternal, Child, and Reproductive Health Initiative, Barcelona Institute for Global Health (ISGlobal), Hospital Clinic—University of Barcelona, Barcelona 08036, Spain; (A.B. (Azucena Bardají)); (E.M.C.); (C.M.), Departamento de Obstetricia y Ginecología, Universidad Industrial de Santander, Bucaramanga 680002, Colombia; (C.H.B.M.); (L.A.G.S.), McGill University Health Centre, McGill University, Montréal, QC H4A 3J1, Canada; (A.B. (Andrea Benedetti)), Department of Infectious Diseases, Hospital Federal dos Servidores do Estado, Rio de Janeiro 22440-901, Brazil; (M.d.L.B.T.); (O.d.C.F.); (E.J.), Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia 2005, Venezuela; (S.B.), Unidad de Atención Primaria a la Salud, Instituto Mexicano del Seguro Social, Ciudad de México 06600, México; (V.H.B.A.), Universidade Federal de Minas Gerais, Minas Gerais 31270-901, Brazil; (F.B.); (M.T.); Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; (E.B.B.), NDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, 1211 Geneva 27, Switzerland; (N.B.); (E.K.); (C.K.); (L.M.); (J.L.S.); (S.S.T.), School of Public Health and Tropical Medicine, Tulane University, New Orleans LA 70112, USA; (P.B. (Pierre Buekens)), Mother and Children Health Research Department, Institute for Clinical Effectiveness and Health Policy, Buenos Aires C1056ABH, Argentina; (M.L.C.), Department of Statistics, University of British Columbia, Vancouver BC V6T 1Z4, Canada; (H.C.); (P.G. (Patrick Gérardin)), Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal QC H3A 1A2, Canada; (M.C.), Paediatric Neurology, Paediatric Medicine, KK Women’s and Children’s Hospital, 229899 Singapore; (D.C.), Institute of Collective Health, Federal University of Bahia, Salvador 40110-909, Brazil; (F.C.), Departmento de Ginecologia e Obstetrícia, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, São Paulo 65470-000, Brazil; (C.M.C.), Departamento de Pediatria, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, Brazil; (A.J.C.), BIOMELAB SAS, Barranquilla 080001, Colombia; (C.C.C.), Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht 3584 CG, The Netherlands; (J.A.A.D.); (V.M.T.d.J.); (K.G.M.M.), Department of Epidemiology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands; (T.P.D.), Departments of Pediatrics and Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine, Children’s National Research Institute, Washington, DC 20052, USA; (R.L.D.), Departamento de Pediatría, Universidad Industrial de Santander, Bucaramanga 680002, Colombia; (L.A.D.M.), Ribeirão Preto Medical School of University of São Paulo, São Paulo 14049-900, Brazil; (G.D.), Centro Provincial de Genética Médica, Cienfuegos 90100, Cuba; (D.M.F.), Children’s Hospital Juvencio Matos, São Luís 65065-545, Brazil; (J.S.G.), Centre for Clinical Investigation (CIC1410), Centre Hospitalier Universitaire de La Réunion, Saint Pierre 97448, Réunion, France; (P.G. (Paul Gustafson)), National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; (S.M.G.); (V.T.T.); (D.V.), Instituto Nacional de Salud—Colombia, Bogotá 111321, Colombia; (M.G.); (M.L.O.M.), División de Vigilancia Epidemiológica de Enfermedades Transmisibles, Instituto Mexicano del Seguro Social, Ciudad de México 06600, Mexico; (C.G.M.), Centro de Investigación, Diagnostico, y Referencia, Centro Colaborador OPS-OMS Para el Estudio del Dengue y su Control, Instituto de Medicina Tropical, Pedro Kourí (IPK), Havana, Cuba; (M.G.G.), Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-901, Brazil; (C.H.), Academic Pediatric Center Suriname, Academic Hospital Paramaribo, Paramaribo, Suriname; (N.H.); (A.J.), Department of Paediatrics and Child Health, Kenyatta National Teaching and Referral Hospital, Nairobi 00202, Kenya; (I.I.), Heidelberg Institute for Global Health, Heidelberg University Hospital, Heidelberg 69120, Germany; (T.J.), Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; (A.I.K.); (M.R.), Department of Virology, Erasmus MC, Rotterdam 3015 CN, The Netherlands; (M.K.), Pediatric—Infectious Diseases, Stanford Hospital, Palo Alto, CA 94304, USA; (A.D.L.B.), Bureau of Communicable Disease, NYC Department of Health and Mental Hygiene, New York, NY 11101, USA; (M.L.); (E.H.L.); (M.P.), Executive Director’s Office, National Centre for Infectious Diseases, 308442 Singapore; (Y.S.L.), Centre for Prognosis Research, School of Primary, Community and Social Care, Keele University, Keele ST5 5BG, UK; (B.L.), Institute of Social and Preventive Medicine, University of Bern, Bern 3012, Switzerland; (N.L.), Windward Islands Research and Education Foundation, St. George’s University, True Blue Point, Grenada; (C.N.L.M.); (T.P.N.), Institutos de Investigaciones Biologicas del Tropico, Universidad de Córdoba, Córdoba 14014, Colombia; (S.M.), Department of Clinical Research, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; (P.M.), Instituto de Pesquisa Professor Joaquim Amorim Neto, Campina Grande, Paraiba 58402-040, Brazil; (A.M.), Research, Science, and Technology Division, Instituto Nacional de Salud—Colombia, Bogotá 111321, Colombia; (M.M.R.), Facultad de Salud Carrera, Universidad Industrial de Santander, Bucaramanga 680002, Colombia; (M.C.M.M.); (L.A.V.), Faculdade de Ciencias Medicas da, Universidade de Pernambuco, Recife 50670-901, Brazil; (D.d.B.M-F.), Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg 69120, Germany; (I.M.); (K.D.R.), Department of Neonatology, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 20231-050, Brazil; (M.E.M.), Departments of Pediatrics and Neurology, The George Washington University School of Medicine, Fetal Medicine Institute, Children’s National Research Institute, Washington, DC 20052, USA; (S.B.M.), División de Laboratorios de Vigilancia e Investigación Epidemiológica, Instituto Mexicano del Seguro Social, Ciudad de México 06600, México; (J.E.M.M.), Departamento de Pediatria, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, São Paulo 14049-900, Brazil; (M.M.M.P.), Department of Medicine, Emory University, Atlanta, Georgia 30322, USA; (M.S.N.), Washington State University Global Health Program, Washington State University, Pullman, WA 99164 USA; (M.K.N.), Department of Dermatologic Diseases, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto 15090-000, Brazil; (M.N.), Paul G. Allen School for Global Animal Health, Washington State University, Nairobi, Kenya; (E.O.), Department of Pediatrics, Faculty of Medicine of Jundiaí, São Paulo 13202-550, Brazil; (S.P.), Communicable Diseases and Environmental Determinants of Health Department, Pan American Health Organization, Washington, DC 20037, USA; (F.P.), Department of Obstetrics and Gynecology, Centre Hospitalier de l’Ouest Guyanais 97320, Saint-Laurent du Maroni, French Guiana; (L.P.), Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital, Lausanne 1011, Switzerland, Department of Pediatrics, D’Or Institute for Research & Education, Rio de Janeiro 22281-100, Brazil; (A.P.B.), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador 40296-710, Brazil; (M.R.); (A.I.K.), Evidence and Intelligence for Action in Health, Pan American Health Organization, Washington, DC 20037, USA; (L.R.), Maternal-Fetal Medicine Unit, Department of Obstetrics, Hospital Universitari Vall d’Hebron, Barcelona 08035, Spain; (C.R.), Hospital Materno Infantil de Goiânia, Health State Secretary, Goiás 74125-090, Brazil; (L.E.P.R.), Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; (N.S.C.), Department of Public Health, Federal University of Maranhão, São Luís 65080-805, Brazil; (A.A.S.), Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Salvador 40296-710, Brasil; (I.C.d.S.), Obstetrics and Gynaecology, Diagnostic (Mother & Baby) Ltd., Lange Park 120110, Trinidad and Tobago; (K.S.), SOSECALI C. Ltd.a. Universidad Católica Santiago de Guayaquil, Guayaquil 090-615, Ecuador; (C.S.S.), Department of Pediatrics, University Hospital Vall d’Hebron, Barcelona 08035, Spain; (A.S.A.), Reference Center for Neurodevelopment, Assistance, and Rehabilitation of Children, State Department of Health of Maranhão, Sao Luís 65076-820, Brazil; (P.S.), Department of Social Medicine, University of São Paulo, São Paulo 01000-000, Brazil; (J.P.S.), Obstetrics Department, Vall d’Hebron Hospital, Barcelona 08035, Spain; (A.S.F.), Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen 9712 CP, The Netherlands; (A.T.), Departamento de Parasitología Médica, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia 2005, Venezuela, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia 74690-900, Brazil; (M.D.T.), The Research Centre Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz), Recife 50670-420, Brazil; (C.M.T.M.), Department of Infectious Hazards Management, World Health Organization, 1211 Geneva 27, Switzerland; (M.D.V.K.), Department of Social Medicine, Federal University of Pernambuco, Recife 50670-420, Brazil; (T.V.B.d.A.), Obstetrics & Gynecology, Hospital General Universitario Gregorio Marañón, Madrid 28007, Spain; (C.V.B.), Centre for Mathematical Sciences, University of Plymouth, Plymouth PL4 8AA, UK; (Y.W.), Division of Global Health Protection, US Centers for Disease Control and Prevention, Nairobi, Kenya; (M.A.W.), Institute of Tropical Medicine, 2000 Antwerp, Belgium, Department of Disease Control, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; (A.W.S.).
 
This commentary describes the creation of the Zika Virus Individual Participant Data Consortium, a global collaboration to address outstanding questions in Zika virus (ZIKV) epidemiology through conducting an individual participant data meta-analysis (IPD-MA). The aims of the IPD-MA are to (1) estimate the absolute and relative risks of miscarriage, fetal loss, and short- and long-term sequelae of fetal exposure; (2) identify and quantify the relative importance of different sources of heterogeneity (e.g., immune profiles, concurrent flavivirus infection) for the risk of adverse fetal, infant, and child outcomes among infants exposed to ZIKV in utero; and (3) develop and validate a prognostic model for the early identification of high-risk pregnancies and inform communication between health care providers and their patients and public health interventions (e.g., vector control strategies, antenatal care, and family planning programs). By leveraging data from a diversity of populations across the world, the IPD-MA will provide a more precise estimate of the risk of adverse ZIKV-related outcomes within clinically relevant subgroups and a quantitative assessment of the generalizability of these estimates across populations and settings. The ZIKV IPD Consortium effort is indicative of the growing recognition that data sharing is a central component of global health security and outbreak response.
 
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