Article
Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Registro en:
SANTIAGO, Rayra P. et al. Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations. Mediators of Inflammation, 2020.
0962-9351
10.1155/2020/3185015
Autor
Santiago, Rayra P.
Figueiredo, Camylla V. B.
Fiuza, Luciana M.
Yahouédéhou, Sètondji C. M. A.
Oliveira, Rodrigo M.
Aleluia, Milena M.
Carvalho, Suellen P.
Fonseca, Cleverson A.
Nascimento, Valma M. L.
Rocha, Larissa C.
Guarda, Caroline Conceição
Gonçalves, Marilda de Souza
Resumen
Coordenação de Aperfeiçoamento de Pessoal de
Nível Superior–Brasil (CAPES)—(Finance Code 001) (RPS,
SCMAY and SPC). The study was also supported by the Conselho
Nacional de Desenvolvimento Científico e Tecnológico
(CNPq) (470959/2014-2 and 405595/2016-6) through a
grant to MSG. Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to
play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation.
Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory
diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as
clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol
(TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than
individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia.
Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG
haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and
CGG haplotypes of TGFBR3 present important alterations in lipid profile.