Article
Optimization of oncological 18F-FDG PET/CT imaging based on a multiparameter analysis
Registro en:
MENEZES, V. O. et al. Optimization of oncological 18F-FDG PET/CT imaging based on a multiparameter analysis. Medical Physics, v. 43, n. 2, p.930-938, 2016.
0094-2405
dx.doi.org/10.1118/1.4940354]
Autor
Menezes, Vinicius Oliveira
Machado, Marcos A. D
Queiroz, Cleiton Cavalcante
Souza, Susana O
d’Errico, Francesco
Namías, Mauro
Larocca, Ticiana Ferreira
Soares, Milena Botelho Pereira
Resumen
Purpose: This paper describes a method to achieve consistent clinical image quality in 18F-FDG
scans accounting for patient habitus, dose regimen, image acquisition, and processing techniques.
Methods: Oncological PET/CT scan data for 58 subjects were evaluated retrospectively to derive
analytical curves that predict image quality. Patient noise equivalent count rate and coefficient of
variation (CV) were used as metrics in their analysis. Optimized acquisition protocols were identified
and prospectively applied to 179 subjects.
Results: The adoption of different schemes for three body mass ranges (<60 kg, 60–90 kg, >90 kg)
allows improved image quality with both point spread function and ordered-subsets expectation
maximization-3D reconstruction methods. The application of this methodology showed that CV
improved significantly (p < 0.0001) in clinical practice.
Conclusions: Consistent oncological PET/CT image quality on a high-performance scanner was
achieved from an analysis of the relations existing between dose regimen, patient habitus, acquisition,
and processing techniques. The proposed methodology may be used by PET/CT centers
to develop protocols to standardize PET/CT imaging procedures and achieve better patient
management and cost-effective operations.