Article
Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major.
Registro en:
SANTIAGO, H. da C. et al. Involvement of the chemokine RANTES (CCL5) in resistance to experimental infection with Leishmania major. Infection and Immunity, v. 72, n. 8, p. 4918-4923, 2004.
0019-9567
10.1128/IAI.72.8.4918–4923.2004
Autor
Santiago, Helton da Costa
Oliveira, Carolina Ferreira
Santiago, Luciana
Ferraz, Fernanda Oliveira
Souza, Daniele da Glória de
Freitas, Luiz Antonio Rodrigues de
Afonso, Luís Carlos Crocco
Teixeira, Mauro Martins
Gazzinelli, Ricardo Tostes
Vieira, Leda Quércia
Resumen
The expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.