Roberto M. Saraiva. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Background: Left atrial (LA) strain (ε) and ε rate (SR) analysis by two-dimensional speckle tracking can represent a new tool to evaluate LA function. To assess its potential value, the authors addressed whether LA ε and SR measured in normal subjects correlates with other Doppler echocardiographic parameters that evaluate LA function and left ventricular function. Methods: Sixty-four healthy subjects were studied. LA ε and SR were calculated with the reference point set at the P wave, which enabled the recognition of peak negative ε (εneg peak), peak positive ε (εpos peak), and the sum of those values, total LA ε (εtot), corresponding to LA contractile, conduit, and reservoir function, respectively. Similarly, peak negative SR (LA SRlate neg peak) during LA contraction, peak positive SR (LA SRpos peak) at the beginning of LV systole, and peak negative SR (LA SRearly neg peak) at the beginning of LV diastole were identified. Results: Global LA εpos peak, εneg peak, and εtot were 23.2 ± 6.7%, −14.6 ± 3.5%, and 37.9 ± 7.6%, respectively. Global LA SRpos peak, SRearly neg peak , and SRlate neg peak were 2.0 ± 0.6 s−1, −2.0 ± 0.6 s−1, and −2.3 ± 0.5 s−1, respectively. The above-described variables derived from analysis of global LA ε and LA SR correlated significantly with Doppler echocardiographic indexes that evaluated the same phase of the cardiac cycle or the same component of the LA function, including indexes derived from mitral inflow, pulmonary vein velocities, tissue Doppler, and LA volumes. Global LA εpos peak, LA εtot, and LA SRearly neg peak also correlated significantly with age or body mass index. Global LA SRlate neg peak also correlated significantly with age. Conclusions: LA ε analysis is a new tool that can be used to evaluate LA function. Further studies are warranted to determine the utility of LA ε in disease states.2020-12-09