Patent

Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide

Polypeptid mit asparaginase-aktivität, expressionskassette, expressionsvektor, wirtszelle, pharmazeutische zusammensetzung, verfahren zur herstellung eines polypeptids mit asparaginase-aktivität und zur vorbeugung oder behandlung von krebs sowie verwendung eines polypeptids

Registro en:
SOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. EP Pat. 3741850 A1, 25 nov. 2020. 45p.
Fundação Oswaldo Cruz
C12N 9/82
C12N 15/55
A61P 35/00
A61K 38/50
C12N 15/66
A61P 35/02
EP19741242.2
BR102018001033-6A2
EP3741850A1
Autor
Souza, Tatiana de Arruda Campos Brasil de
Zanchin, Nilson Ivo Tonin
Morais, Stephanie Bath de
Institución
Resumen
The present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer.
 
Brasil
 
Organização Mundial para Propriedade Intelectual OMPI
 
China
 
Escritório de Patentes Europeu
 
Estados Unidos da América
 
Índia
 
Canadá
 
Materias

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