Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node

dc.creatorAggio, Juliana Bernardi
dc.creatorKrmeska, Veronika
dc.creatorFerguson, Brian J.
dc.creatorWowk, Pryscilla Fanini
dc.creatorRothfuchs, Antonio Gigliotti
dc.date2021-03-12T18:49:54Z
dc.date2021-03-12T18:49:54Z
dc.date2021
dc.date.accessioned2023-09-26T21:37:31Z
dc.date.available2023-09-26T21:37:31Z
dc.identifierAGGIO, Juliana Bernardi et al. Vaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node. The Journal of Immunology, p. 776-784, 2021.
dc.identifier1550-6606
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/46354
dc.identifierhttps://doi.org/10.4049/jimmunol.2000928
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8873039
dc.descriptionThere is a paucity of information on dendritic cell (DC) responses to vaccinia virus (VACV), including the traffic of DCs to the draining lymph node (dLN). In this study, using a mouse model of infection, we studied skin DC migration in response to VACV and compared it with the tuberculosis vaccine Mycobacterium bovis bacille Calmette–Gue´rin (BCG), another live attenuated vaccine administered via the skin. In stark contrast to BCG, skin DCs did not relocate to the dLN in response to VACV. Infection with UV-inactivated VACV or modified VACVAnkara promoted DC movement to the dLN, indicating that interference with skin DC migration requires replication-competent VACV. This suppressive effect of VACV was capable of mitigating responses to a secondary challenge with BCG in the skin, ablating DC migration, reducing BCG transport, and delaying CD4+ T cell priming in the dLN. Expression of inflammatory mediators associated with BCG-triggered DC migration were absent from virus-injected skin, suggesting that other pathways invoke DC movement in response to replication-deficient VACV. Despite adamant suppression of DC migration, VACV was still detected early in the dLN and primed Ag-specific CD4+ T cells. In summary, VACV blocks skin DC mobilization from the site of infection while retaining the ability to access the dLN to prime CD4+ T cells.
dc.formatapplication/pdf
dc.languagepor
dc.publisherThe American Association of Immunologists
dc.rightsopen access
dc.subjectBacillus Calmette-Guérin
dc.subjectBCG
dc.subjectVaccinia virus
dc.subjectDendritic Cells
dc.subjectLymph Nodes
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectVirus Vaccinia
dc.subjectCélulas Dendríticas
dc.subjectGanglios Linfáticos
dc.subjectLinfocitos T CD4-Positivos
dc.subjectVirus de la vaccine
dc.subjectCellules dendritiques
dc.subjectNoeuds lymphatiques
dc.subjectLymphocytes T CD4+
dc.subjectVírus Vaccinia
dc.subjectCélulas Dendríticas
dc.subjectMycobacterium bovis
dc.subjectLinfonodos
dc.subjectLinfócitos T CD4-Positivos
dc.titleVaccinia virus infection inhibits skin dendritic cell migration to the draining lymph node
dc.typeArticle


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