Article
Malaria and leishmaniasis: Updates on co-infection
Registro en:
ORNELAS-GARCIA, Uila ; CUERVO, Patricia; GOMES, Flávia Lima Ribeiro. Malaria and leishmaniasis: Updates on co-infection. Frontiers in Immunology, v.14, 1122411, p. 1 - 10, Feb. 2023.
1664-3224
10.3389/fimmu.2023.1122411
Autor
Ornellas-Garcia, Uyla
Cuerco, Patricia
Gomes, Flávia Lima Ribeiro
Resumen
Malaria and leishmaniasis are endemic parasitic diseases in tropical and
subtropical countries. Although the overlap of these diseases in the same host
is frequently described, co-infection remains a neglected issue in the medical
and scientific community. The complex relationship of concomitant infections
with Plasmodium spp. and Leishmania spp. is highlighted in studies of natural and
experimental co-infections, showing how this “dual” infection can exacerbate or
suppress an effective immune response to these protozoa. Thus, a Plasmodium
infection preceding or following Leishmania infection can impact the clinical
course, accurate diagnosis, and management of leishmaniasis, and vice versa.
The concept that in nature we are affected by concomitant infections reinforces
the need to address the theme and ensure its due importance. In this review we
explore and describe the studies available in the literature on Plasmodium spp.
and Leishmania spp. co-infection, the scenarios, and the factors that may
influence the course of these diseases.