Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes

dc.creatorFreitas, Carla Rangel Leite
dc.creatorBarbosa Junior, Aryon de Almeida
dc.creatorFernandes, André L. M
dc.creatorAndrade, Zilton de Araújo
dc.date2012-10-04T21:35:19Z
dc.date2012-10-04T21:35:19Z
dc.date1999
dc.date.accessioned2023-09-26T21:21:23Z
dc.date.available2023-09-26T21:21:23Z
dc.identifierFREITAS, C.R. et al. Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes. Memórias do Instituto Oswaldo Cruz, v. 94, n. 6, p. 815-22, nov.-dec. 1999.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5648
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8872118
dc.descriptionHistological, ultrastructural, morphometric and immunohistochemical data obtained from the study of spleens removed by splenectomy from 34 patients with advanced hepatosplenic schistosomiasis revealed that the main alterations were congestive dilatation of the venous sinuses and diffuse thickening of the splenic cords. Splenic cord thickening was due to an increase of its matrix components, especially type IV collagen and laminin, with the conspicuous absence of interstitial collagens, either of type I or type III. Deposition of interstitial collagens (types I and III) occurred in scattered, small focal areas of the red pulp, but in the outside of the walls of the venous sinuses, in lymph follicles, marginal zone, in the vicinity of fibrous trabeculae and in sidero-sclerotic nodules. However, fibrosis was not a prominent change in schistosomal splenomegaly and thus the designation "fibro-congestive splenomegaly" seems inadequate. Lymph follicles exhibited variable degrees of atrophy, hyperplasia and fibrous replacement, sometimes all of them seen in different follicles of the same spleen and even in the same examined section. Changes in white pulp did not seem to greatly contribute to increasing spleen size and weight, when compared to the much more significant red pulp enlargement.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSplenomegaly
dc.subjectHepatosplenic schistosomiais
dc.subjectExtra-cellular matrix
dc.subjectHistopathology
dc.subjectMorphometry
dc.subjectMatriz Extracelular/patologia
dc.subjectHepatopatias Parasitárias/patologia
dc.subjectEsquistossomose/patologia
dc.subjectEsplenopatias/patologia
dc.subjectEsplenopatias/parasitologia
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectFeminino
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.titlePathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes
dc.typeArticle


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