Phylodynamics of influenza A(H3N2) in South America, 1999-2012

dc.creatorBorn, Priscila Silva
dc.creatorSiqueira, Marilda Agudo Mendonça Teixeira de
dc.creatorFaria, Nuno Rodrigues
dc.creatorResende, Paola Cristina
dc.creatorMotta, Fernando Couto
dc.creatorBello, Gonzalo
dc.date2016-12-27T12:29:59Z
dc.date2016-12-27T12:29:59Z
dc.date2016
dc.date.accessioned2023-09-26T21:18:51Z
dc.date.available2023-09-26T21:18:51Z
dc.identifierBORN, Priscila Silva; et al. Phylodynamics of influenza A(H3N2) in South America, 1999–2012. Infection, Genetics and Evolution , v.43, p.312–320, 2016.
dc.identifier1567-1348
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/16572
dc.identifier10.1016/j.meegid.2016.06.012
dc.identifier1567-7257
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8871975
dc.descriptionThe limited influenza A(H3N2) genetic data available from the Southern Hemisphere (particularly from Africa and Latin America), constrains the accurate reconstruction of viral dissemination dynamics within those regions. Our objective was to describe the spatial dissemination dynamics of influenza A(H3N2) within South America. A total of 469 sequences of the HA1 portion of the hemagglutinin gene (HA) from influenza A(H3N2) viruses sampled in temperate and tropical South American countries between 1999 and 2012 were combined with available contemporary sequences from Australia, Hong Kong, United Kingdom and the United States. Phylogenetic analyses revealed that influenza A(H3N2) sequences from South America were highly intermixed with sequences from other geographical regions, although a clear geographic virus population structure was detected globally. We identified 14 clades mostly (≥80%) composed of influenza sequences from South American countries. Bayesian phylogeographic analyses of those clades support a significant role of both temperate and tropical regions in the introduction and dissemination of new influenza A(H3N2) strains within South America and identify an intensive bidirectional viral exchange between different geographical areas. These findings indicate that seasonal influenza A(H3N2) epidemics in South America are seeded by both the continuous importation of viral variants from other geographic regions and the short-term persistence of local lineages. This study also supports a complex metapopulation model of influenza A(H3N2) dissemination in South America, with no preferential direction in viral movement between temperate and tropical regions.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectVírus da Influenza A
dc.subjectEvolução viral
dc.subjectFilogeografia
dc.subjectAmérica do Sul
dc.subjectInfluenza A
dc.subjectH3N2
dc.subjectViral evolution
dc.subjectPhylogeography
dc.subjectSouth America
dc.titlePhylodynamics of influenza A(H3N2) in South America, 1999-2012
dc.typeArticle


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