Article
Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases
Registro en:
MAYA-MONTEIRO, Clarissa M. et al. Lipid Droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases. Neuro-endocrinology, p. 1-41, May 2020.
0028-3835
10.1159/000508735
1423-0194
Autor
Maya-Monteiro, Clarissa M.
Silva, Felipe Corrêa da
Hofmann, Sussana S.
Hesselink, Matthijs K. C.
la Fleur, Sussanne E.
Yi, Chun-Xia
Resumen
In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism,
inflammation and insulin resistance. Little is known about the brain LDs. Objectives: We
hypothesised that hypothalamic LDs would be altered in metabolic diseases. Methods: We
used immunofluorescence for the specific LD protein, PLIN2, as the marker to visualize and
quantify LDs.