Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis.

dc.creatorCardoso, Luciana Santos
dc.creatorRocha Barreto, Andréia de Souza
dc.creatorFernandes, Jamille Souza
dc.creatorOliveira, Ricardo Riccio
dc.creatorSouza, Robson da Paixão de
dc.creatorCarvalho Filho, Edgar Marcelino
dc.creatorAraujo, Maria Ilma
dc.date2014-11-10T19:21:44Z
dc.date2014-11-10T19:21:44Z
dc.date2013
dc.date.accessioned2023-09-26T21:08:50Z
dc.date.available2023-09-26T21:08:50Z
dc.identifierCARDOSO, L. S. et al. Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis. Clinical Developmental Immunology, p. 710647, 2013.
dc.identifier1740-2530
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8782
dc.identifierdx.doi.org/10.1155/2013/710647
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869889
dc.descriptionThe Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. Results. The frequency of CD4(+)CD28(+) T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4(+) T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8(+) T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8(+) T cells, CD4(+)CD25(high) T cells, and CD4(+)CTLA-4(+) T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4(+)CD25(low) cells did not differ between groups. Conclusion. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectFibrose/etiologia
dc.subjectSubpopulações de Linfócitos/imunologia
dc.subjectSistema Porta/patologia
dc.subjectEsquistossomose/complicações
dc.subjectEsquistossomose/complicações
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectIdoso
dc.subjectBrasil
dc.subjectLinfócitos T CD4-Positivos/imunologia
dc.subjectLinfócitos T CD8-Positivos/metabolismo
dc.subjectCriança
dc.subjectEstudos Transversais
dc.subjectFeminino
dc.subjectHumanos
dc.subjectAtivação Linfocitária/imunologia
dc.subjectSubpopulações de Linfócitos/metabolismo
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectEsquistossomose/diagnóstico
dc.subjectAdulto Jovem
dc.titleImpaired lymphocyte profile in schistosomiasis patients with periportal fibrosis.
dc.typeArticle


Este ítem pertenece a la siguiente institución