Article
Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
Registro en:
COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.
0001-706X
Autor
Costa, Af Ali Uthant Moreira Lima da
Abreu, Ana Lucia
Gomes, Claudia Maria de Castro
Saldanha, Ana Cristina Rodrigues
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Corbett, Carlos Eduardo Pereira
Resumen
Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with
success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous
form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible
to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis
(DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After
90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense
parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue.
The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction
and secondarily affect the joints