Article
Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: implications for pre-exposure prophylaxis adherence monitoring
Registro en:
GANDHI, Monica. et al. Strong correlation between concentrations of tenofovir (TFV) emtricitabine (FTC) in hair and TFV diphosphate and FTC triphosphate in dried blood spots in the iPrEx open label extension: implications for pre-exposure prophylaxis adherence monitoring. Journal of Infectious Diseases, v. 212, n. 9, p. 1402-1406, 2015.
0022-1899
10.1093/infdis/jiv239
Autor
Gandhi, Monica
Glidden, David V.
Liu, Albert
Anderson, Peter L.
Horng, Howard
Defechereux, Patricia
Guanira, Juan V.
Grinsztejn, Beatriz
Chariyalertsak, Suwat
Bekker, Linda-Gail
Grant, Robert M.
iPrEx Study Team
Resumen
iPrEx Study Team: Javier Lama, Mauro Schechter, Esper G. Kallas, Valdilea Veloso, Kenneth Mayer, Susan Buchbinder, Orlando Montoya, Rivet Amico, Kim Koester, Kathy Mulligan, Martin Casapia, Leslie Z. Benet, Yong Huang, Shirley Yee, Karen Kuncz, Alexander Louie, San Francisco, Ruth Greenblatt, Phyllis Tien, and Bradley Aouizerat Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P < .001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P < .001); hair FTC/DBS TFV-DP (r = 0.74; P < .001); hair FTC/DBS FTC-TP (r = 0.587; P < .001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes. 2028-08-30