Article
Biological Roles of Peptidases in Trypanosomatids
Registro en:
VERMELHO, Alane Beatriz; et al. Biological roles of Peptidases in Trypanosomatids. The Open Parsitology Journal, v.4, p.5-23, 2010.
1874-4214
Autor
Vermelho, Alane Beatriz
Branquinha, Marta Helena
d`Avila-Levy, Claudia M.
Santos, André Luis Souza dos
Dias, Edilma Paraguai de Souza
Melo, Ana Cristina Nogueira de
Resumen
In this review, we report the recent developments in the characterization of peptidases and their possible biological functions in the Trypanosomatidae family. The focus will be on peptidases from Trypanosoma cruzi, Leishmania spp., African trypanosomes and plant and insect trypanosomatids. There are numerous events in parasite development where the involvement of peptidases has been established, and they will be approached in the present review. Also in this review we will discuss the central roles have been proposed for peptidases in diverse processes such as virulence, host cell interaction and invasion, catabolism of host proteins, differentiation, cell cycle progression and both stimulation and evasion of host immune responses.
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