Functional Characterization of a Cassette-Specific Promoter in the Class 1 Integron-Associated qnrVC1 Gene

dc.creatorFonseca, Érica Lourenço da
dc.creatorVicente, Ana Carolina Paulo
dc.date2017-05-23T18:25:46Z
dc.date2017-05-23T18:25:46Z
dc.date2012
dc.date.accessioned2023-09-26T21:06:14Z
dc.date.available2023-09-26T21:06:14Z
dc.identifierFONSECA, Érica Lourenço da; VICENTE, Ana Carolina Paulo. Functional Characterization of a Cassette-Specific Promoter in the Class 1 Integron-Associated qnrVC1 Gene. Antimicrobial Agents and Chemotherapy, v. 56, n. 6, p. 3392–3394, Jun. 2012.
dc.identifier0066-4804
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19002
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8869198
dc.descriptionIntegrons are natural expression vectors due to the presence of an intrinsic promoter (Pc). Although rare, gene cassettes can harbor their own promoter. This study determined the functionality of an internal promoter in the qnrVC1 cassette whose presence was suggested by a level of transcription similar to that of the preceding cassette (aadA2) and confirmed by in silico analysis. Its functionality was determined by 5= rapid amplification of cDNA ends (RACE) and cloning into promoter-probe vectors. PqnrVC was found in the qnrVC cassette family, stressing its role in contributing to resistance manifestation.
dc.formatapplication/pdf
dc.languagepor
dc.rightsopen access
dc.subjectGene
dc.subjectqnrVC1 Gene
dc.subjectIntegron
dc.subjectintrinsic promoter
dc.titleFunctional Characterization of a Cassette-Specific Promoter in the Class 1 Integron-Associated qnrVC1 Gene
dc.typeArticle


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