Article
Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain
Registro en:
CARVALHO, João Marcos da Silva et al. Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain. Advances in Rheumatology, v. 62, n. 31, p. 1-7, 2022.
2523-3106
10.1186/s42358-022-00259-y
Autor
Carvalho, João Marcos da Silva
Campos, Eugênia Maria Teixeira de Araújo
Ferreira, José Luiz Nunes
Carvalho, Huliana Mourão
Carneiro Neto, José Abraão
Carneiro, Tássila de Oliveira
Carvalho, Edgar Marcelino
Resumen
Fundação Maria Emília Pedreira Freire de Carvalho.
Conselho Nacional de Pesquisa (CNPq).
Ministério da Ciência, Tecnologia e Inovação.
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Background: Joint pain in the absence or with little synovitis is observed in a large percentage of HTLV-1 infected subjects. As the virus infect CD4+and CD8+positive, macrophages and B cells an exaggerated production of pro infammatory cytokines is detected in these patients. However, the possible association of HTLV-1 infection with auto immune diseases has not been documented defnitively and the clinical characteristics of HTLV-1 associated arthropa thy has not been defned. The objective this study is to describe clinic and radiographic features in HTLV-1-infected individuals with complaints of joint pain. Methods: Cross-sectional study enrolling HTLV-1-infected individuals with chronic joint pain, aged up to 75 years, both genders and seronegative controls with osteoarthritis. All participants underwent conventional radiography of the hips, knees and ankles. Results: Eighty-one HTLV-1 infected patients and 30 subjects with osteoarthritis participated in the study. Polyarticu lar and symmetrical arthritis prevailed in the HTLV-1 positive group (54%), while oligoarticular and asymmetrical (44%) were more common in controls (p<0.05). The frequency of enthesophytes (90%) in HTLV-1-infected patients was greater than in the control group (73%) (p<0.05). Radiographic features were similar in HTLV-1 carriers and in patients with probable or defnite HTLV-1 associated myelopathy. The presence of enthesophytes in the absence of joint space reduction or osteophytes was only observed in HTLV-1-infected individuals (p<0.001). Magnetic resonance imaging of the ankles of fve HTLV-1-infected patients and fve controls demonstrated a higher frequency of enthesitis, bursitis and osteitis in the HTLV-1 infected group. Conclusion: HTLV-1-associated arthropathy is clinically characterized by symmetrical polyarthralgia and the main
radiological fnding is the presence of enthesophytes in the absence of osteophytes and joint space narrowing.